接受因子替代疗法的血友病患者的血浆蛋白变化
Plasma protein variations in hemophiliacs receiving factor replacement therapy.
作者信息
Singh Monica, Singh Puneetpal, Kaur Harsurinder
机构信息
Department of Human Biology, Punjabi University, Patiala, India.
出版信息
Indian J Pediatr. 2007 May;74(5):459-62. doi: 10.1007/s12098-007-0078-y.
OBJECTIVE
Post transfusion manifestations and its affiliated factors are vital to understand in a disease like hemophilia where multi-transfusions are given to the patients.
METHODS
To investigate the implications of factor replacement therapy on plasma proteins, 52 hemophiliacs and 68 carrier females were examined for 12 plasma proteins using various electrophoretic techniques.
RESULTS
Severe hemophiliacs showed raised levels ( p< 0.05) of a2 M, IgG and Albumins where values were found to be 4.78 +/- 0.865 g/l, 21.48 +/- 3.38 g/l, 66.26 +/- 11.92 g/l respectively at 95% confidence intervals however, controls and carriers showed trivial variations.
CONCLUSION
Juxtaposing the dissimilarities of 12 plasma proteins in carriers, controls and hemophiliacs, it has been gleaned that factor replacement therapy do play role when seen in severe hemophiliacs with raised levels.
目的
在血友病这种需要对患者进行多次输血的疾病中，了解输血后表现及其相关因素至关重要。
方法
为研究因子替代疗法对血浆蛋白的影响，采用多种电泳技术对52名血友病患者和68名携带者女性进行了12种血浆蛋白检测。
结果
重度血友病患者的α2M、IgG和白蛋白水平升高（p<0.05），在95%置信区间时，其值分别为4.78±0.865g/l、21.48±3.38g/l、66.26±11.92g/l，然而，对照组和携带者的变化微不足道。
结论
对比携带者、对照组和血友病患者中12种血浆蛋白的差异，发现在重度血友病患者中，当水平升高时，因子替代疗法确实发挥了作用。
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