内皮脂肪酶基因多态性与急性心肌梗死相关，独立于高密度脂蛋白胆固醇水平。

Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels.

作者信息

Shimizu Masakatsu, Kanazawa Kenji, Hirata Ken-ichi, Ishida Tatsuro, Hiraoka Eiji, Matsuda Yasuaki, Iwai Chikao, Miyamoto Yoshitomo, Hashimoto Masayoshi, Kajiya Teishi, Akita Hozuka, Yokoyama Mitsuhiro

机构信息

Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

出版信息

Circ J. 2007 Jun;71(6):842-6. doi: 10.1253/circj.71.842.

DOI:10.1253/circj.71.842

PMID:17526978

Abstract

BACKGROUND

Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism and promotes monocytes recruitment. The local expression of EL could influence atherogenesis directly, in addition to its systemic role in HDL metabolism. The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial infarction (AMI).

METHODS AND RESULTS

A case-control study of 107 AMI patients and 107 control subjects was conducted. T allele frequency was lower in the AMI group than in controls (0.18 vs 0.26, p<0.05). No significant association was found between the 584C/T polymorphism and HDL-C levels. Multivariate regression analyses showed that the association of the T allele with AMI was statistically significant and independent of other risk factors when age, sex, hypertension, hypercholesterolemia, and diabetes mellitus were included in the analyses (odds ratio (OR), 0.52; 95% confidence interval (95% CI) 0.28-0.98; p=0.04). However, when smoking status was included, the association of the T allele with AMI did not remain statistically significant (OR, 0.61; 95% CI 0.32-1.18; p=0.14).

CONCLUSIONS

The 584C/T polymorphism of the EL gene was associated with AMI independently of HDL-C levels and thus may be involved in the pathogenesis of AMI.

摘要

背景

内皮脂肪酶（EL）是高密度脂蛋白胆固醇（HDL-C）代谢的主要决定因素，并促进单核细胞募集。EL的局部表达除了在HDL代谢中发挥全身作用外，还可能直接影响动脉粥样硬化的发生。EL基因存在常见的584C/T多态性，但尚不清楚这种多态性是否与HDL-C水平或急性心肌梗死（AMI）相关。

方法与结果

对107例AMI患者和107例对照者进行了病例对照研究。AMI组的T等位基因频率低于对照组（0.18对0.26，p<0.05）。未发现584C/T多态性与HDL-C水平之间存在显著关联。多变量回归分析显示，在分析中纳入年龄、性别、高血压、高胆固醇血症和糖尿病时，T等位基因与AMI的关联具有统计学意义且独立于其他危险因素（比值比（OR）为0.52；95%置信区间（95%CI）为0.28-0.98；p=0.04）。然而，纳入吸烟状态后，T等位基因与AMI的关联不再具有统计学意义（OR为0.61；95%CI为0.32-1.18；p=0.14）。