激素对移植于裸鼠体内的雌激素受体阳性人乳腺癌（MCF-7）肿瘤生长及免疫反应性胰岛素样生长因子-1的影响。

Effects of hormones on tumor growth and immunoreactive insulin-like growth factor-1 of estrogen receptor-positive human breast cancer (MCF-7) transplanted in nude mice.

作者信息

Noguchi M, Koyasaki N, Miyazaki I, Mizukami Y

机构信息

Operation Center, Kanazawa University Hospital.

出版信息

Jpn J Cancer Res. 1991 Nov;82(11):1199-202. doi: 10.1111/j.1349-7006.1991.tb01780.x.

DOI:10.1111/j.1349-7006.1991.tb01780.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918318/

Abstract

The effects of estrogens and tamoxifen were analyzed on estrogen receptor-positive human breast cancer (MCF-7) transplanted into athymic nude mice. It was found that (1) the tumor growth and the proportion of 3H-thymidine-labeled cells were significantly increased in the 17 beta-estradiol dipropionate (E2) group, but significantly decreased in the tamoxifen (TAM) group with respect to the control group, and (2) the tumor content of insulin-like growth factor-1 (IGF-1) and the rate of IGF-1-positive cells were significantly lower in the E2 group, but significantly higher in the TAM group than in the control group. It was concluded that the tumor content of IGF-1 and the proportion of IGF-I-positive cells were inversely correlated to the tumor growth and the 3H-thymidine labeling index in vivo.

摘要

分析了雌激素和他莫昔芬对移植到无胸腺裸鼠体内的雌激素受体阳性人乳腺癌（MCF-7）的影响。结果发现：（1）与对照组相比，17β-雌二醇二丙酸酯（E2）组的肿瘤生长及3H-胸腺嘧啶核苷标记细胞比例显著增加，而他莫昔芬（TAM）组则显著降低；（2）E2组胰岛素样生长因子-1（IGF-1）的肿瘤含量及IGF-1阳性细胞率显著低于对照组，而TAM组则显著高于对照组。得出结论：体内IGF-1的肿瘤含量及IGF-I阳性细胞比例与肿瘤生长及3H-胸腺嘧啶核苷标记指数呈负相关。

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本文引用的文献

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Acute effects of growth hormone administration: vitamin A and visceral protein concentrations.生长激素给药的急性效应：维生素A与内脏蛋白浓度

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Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth.雌激素诱导的乳腺癌细胞因子可部分替代雌激素促进肿瘤生长。

Science. 1986 Jun 20;232(4757):1540-3. doi: 10.1126/science.3715461.

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Maturitas. 1988 Mar;9(4):297-302. doi: 10.1016/0378-5122(88)90094-1.

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Secreted growth factors from estrogen receptor-negative human breast cancer do not support growth of estrogen receptor-positive breast cancer in the nude mouse model.雌激素受体阴性的人乳腺癌分泌的生长因子在裸鼠模型中不能支持雌激素受体阳性乳腺癌的生长。

Breast Cancer Res Treat. 1988 Jul;11(3):211-9. doi: 10.1007/BF01807279.

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J Clin Endocrinol Metab. 1986 Aug;63(2):424-32. doi: 10.1210/jcem-63-2-424.

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8th San Antonio Breast Cancer Symposium--Plenary lecture. Autocrine and paracrine growth regulation of human breast cancer.第八届圣安东尼奥乳腺癌研讨会——全会演讲。人类乳腺癌的自分泌和旁分泌生长调节。

Breast Cancer Res Treat. 1986;7(2):59-70. doi: 10.1007/BF01806790.

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