Noguchi M, Thomas M, Koyasaki N, Ohta N, Taniya T, Kitagawa H, Miyazaki I, Mizukami Y
Operation Center, Kanazawa University Hospital, School of Medicine, Japan.
Mol Cell Endocrinol. 1993 Mar;92(1):69-76. doi: 10.1016/0303-7207(93)90076-v.
The influence of estrogens and tamoxifen on estrogen receptor (ER)-positive human breast cancer (MCF-7) cells transplanted into athymic nude mice was investigated. The mice were divided into the following three groups: (1) an E2 group with mice receiving 17 beta-estradiol dipropionate; (2) a TAM group with mice receiving tamoxifen; (3) a control group with mice given no hormone. (1) Tumor growth was significantly increased in the E2 group, but significantly decreased in the TAM group compared to control; (2) the tumor contents of insulin-like growth factor-I (IGF-I) and the rate of IGF-I-positive cells were significantly lower in the E2 group, but significantly higher in the TAM groups compared to control; (3) the IGF-I-positive cell rates were in significant inverse correlation with the [3H]thymidine-labeled cell rates in the E2, TAM and control groups. Thus, the tumor contents of IGF-I and the rate of IGF-I-positive cells were inversely correlated to the tumor growth and the [3H]thymidine-labeled cell rate in this in vivo study, although IGF-I is known to be a mitogen for breast cancer cells in vitro. Further studies are necessary to answer the questions as to the in vivo roles of immunoreactive IGF-I in ER-positive breast cancer.
研究了雌激素和他莫昔芬对移植到无胸腺裸鼠体内的雌激素受体（ER）阳性人乳腺癌（MCF - 7）细胞的影响。将小鼠分为以下三组：（1）E2组，小鼠接受二丙酸17β - 雌二醇；（2）TAM组，小鼠接受他莫昔芬；（3）对照组，小鼠不给予激素。（1）与对照组相比，E2组肿瘤生长显著增加，而TAM组显著降低；（2）与对照组相比，E2组胰岛素样生长因子 - I（IGF - I）的肿瘤含量和IGF - I阳性细胞率显著降低，而TAM组显著升高；（3）E2组、TAM组和对照组中IGF - I阳性细胞率与[³H]胸腺嘧啶核苷标记的细胞率呈显著负相关。因此，在这项体内研究中，尽管已知IGF - I在体外是乳腺癌细胞的有丝分裂原，但IGF - I的肿瘤含量和IGF - I阳性细胞率与肿瘤生长及[³H]胸腺嘧啶核苷标记的细胞率呈负相关。需要进一步研究以回答免疫反应性IGF - I在ER阳性乳腺癌体内作用的相关问题。
