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光交联聚苯乙烯壳层金核纳米粒子的稳定性增强及生物共轭作用

Enhanced stability and bioconjugation of photo-cross-linked polystyrene-shell, Au-core nanoparticles.

作者信息

Chen Ying, Cho Juhee, Young Alexi, Taton T Andrew

机构信息

Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.

出版信息

Langmuir. 2007 Jul 3;23(14):7491-7. doi: 10.1021/la700494e. Epub 2007 May 27.

DOI:10.1021/la700494e
PMID:17530871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2564825/
Abstract

Encapsulating Au nanoparticles within a shell of photo-cross-linked block copolymer surfactant dramatically improves the physical and chemical stability of the nanoparticles, particularly when they are applied as bioconjugates. Photo-cross-linkable block copolymer amphiphiles [polystyrene-co-poly(4-vinyl benzophenone)]-block-poly(acrylic acid) [(PS-co-PVBP)-b-PAA] and [poly(styrene)-co-poly(4-vinyl benzophenone)]-block-poly(ethylene oxide) [(PS-co-PVBP)-b-PEO] were assembled around Au nanoparticles ranging from 12 to 108 nm in diameter. UV irradiation cross-linked the PVBP groups on the polymer to yield particles that withstood extremes of temperature, ionic strength, and chemical etching. Streptavidin was attached to [PS-co-PVBP]-b-PAA-coated particles using the same noncovalent and covalent conjugation protocols used to bind biomolecules to divinylbenzene-cross-linked PS microspheres. We expect that these particles will be useful as plasmonic, highly light-scattering and light-absorbing analogs to fluorescently labeled PS nanospheres.

摘要

将金纳米颗粒封装在光交联嵌段共聚物表面活性剂的壳层中，可显著提高纳米颗粒的物理和化学稳定性，尤其是当它们用作生物共轭物时。可光交联的嵌段共聚物两亲物[聚苯乙烯-共-聚（4-乙烯基二苯甲酮）]-嵌段-聚丙烯酸[（PS-共-PVBP）-b-PAA]和[聚苯乙烯]-共-聚（4-乙烯基二苯甲酮）]-嵌段-聚环氧乙烷[（PS-共-PVBP）-b-PEO]围绕直径为12至108nm的金纳米颗粒组装。紫外线照射使聚合物上的PVBP基团交联，从而产生能够耐受极端温度、离子强度和化学蚀刻的颗粒。使用与将生物分子结合到二乙烯基苯交联的PS微球相同的非共价和共价共轭方案，将链霉亲和素连接到[PS-共-PVBP]-b-PAA包被的颗粒上。我们预计这些颗粒将作为等离子体、高散射光和光吸收类似物，用于荧光标记的PS纳米球。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/b71cf02914a2/nihms-62427-f0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/861813bc78dc/nihms-62427-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/0f1063cbaf23/nihms-62427-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/e8879f711b11/nihms-62427-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/f3ef06fe8839/nihms-62427-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/b71cf02914a2/nihms-62427-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/32f82efabea5/nihms-62427-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/460c031b34d1/nihms-62427-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/fc1a8cf4b0d7/nihms-62427-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/861813bc78dc/nihms-62427-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/0f1063cbaf23/nihms-62427-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/e8879f711b11/nihms-62427-f0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caac/2564825/b71cf02914a2/nihms-62427-f0008.jpg

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本文引用的文献

1
Thiol-mediated degradation of DNA adsorbed on a colloidal gold surface.硫醇介导的吸附在胶体金表面的DNA降解。
J Chem Technol Biotechnol. 2003 Apr;78(4):471-473. doi: 10.1002/jctb.806. Epub 2003 Mar 19.
2
Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science.纳米颗粒、蛋白质与核酸：生物技术邂逅材料科学。
Angew Chem Int Ed Engl. 2001 Nov 19;40(22):4128-4158. doi: 10.1002/1521-3773(20011119)40:22<4128::AID-ANIE4128>3.0.CO;2-S.
3
Covalent DNA-Streptavidin Conjugates as Building Blocks for Novel Biometallic Nanostructures.作为新型生物金属纳米结构构建单元的共价DNA-链霉亲和素缀合物
Angew Chem Int Ed Engl. 1998 Sep 4;37(16):2265-2268. doi: 10.1002/(SICI)1521-3773(19980904)37:16<2265::AID-ANIE2265>3.0.CO;2-F.
4
Crosslinked, Glassy Styrenic Surfactants Stabilize Quantum Dots Against Environmental Extremes.交联玻璃态苯乙烯类表面活性剂可使量子点在极端环境下保持稳定。
J Mater Chem. 2009;19(35):6324-6327. doi: 10.1039/B902275A. Epub 2009 Jun 19.
5
Metal nanoparticles as labels for heterogeneous, chip-based DNA detection.金属纳米颗粒作为基于芯片的异质DNA检测的标记物。
Nanotechnology. 2003 Dec;14(12):R63-73. doi: 10.1088/0957-4484/14/12/R01. Epub 2003 Oct 17.
6
A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting.一种用于测量核酸酶活性和DNA足迹的纳米等离子体分子尺。
Nat Nanotechnol. 2006 Oct;1(1):47-52. doi: 10.1038/nnano.2006.51.
7
Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers.多形貌的“平头”状聚苯乙烯-b-聚丙烯酸嵌段共聚物聚集态。
Science. 1995 Jun 23;268(5218):1728-31. doi: 10.1126/science.268.5218.1728.
8
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9
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10
Effect of hydrophobicity inside PEO-PPO-PEO block copolymer micelles on the stabilization of gold nanoparticles: experiments.聚环氧乙烷-聚环氧丙烷-聚环氧乙烷嵌段共聚物胶束内部疏水性对金纳米颗粒稳定性的影响：实验
Langmuir. 2006 Nov 7;22(23):9704-11. doi: 10.1021/la061093m.