de Paleville Daniela Terson, Topp Robert V, Swank Ann M
Exercise Physiology Laboratory, University of Louisville, Louisville, Kentucky 40292, USA.
J Strength Cond Res. 2007 May;21(2):635-7. doi: 10.1519/R-19735.1.
Treatment for breast cancer patients includes surgical removal of the tumor followed by chemotherapy. Chemotherapy frequently results in difficult to manage symptoms that threaten compliance with the therapy. Symptoms include fatigue, declines in functional ability, muscle wasting, and a decreased quality of life. Preparing the body to tolerate a stressful event such as chemotherapy has been termed "prehabilitation". This case study determined the efficacy of introducing aerobic training 1 week prior to and continuing through 8 weeks of chemotherapy on fatigue and functional ability in a 42-year-old newly diagnosed breast cancer patient. The patient participated in a supervised and home-based walking program. Fatigue during daily activities and functional ability (12-minute walk, ascending and descending stairs, sit to stand, getting to and rising from the floor, 30-second bicep curl) were measured before and after exercise training. Results indicate that 5 of 7 functional measures demonstrated improvement, ranging from 23.4- 54.5%. In addition, fatigue while performing activities of daily living, as well as following the performance of the functional tasks, was reduced. The findings of this case study indicate that fatigue can be decreased and functional ability can be improved as a result of aerobic training initiated 1 week before and continued throughout chemotherapy. This case study presents a novel approach to introducing exercise prior to and continued during 8 weeks of chemotherapy in a way that may reduce the cumulative effects of this stressor.
乳腺癌患者的治疗包括手术切除肿瘤，随后进行化疗。化疗常常会导致难以控制的症状，这些症状会影响患者对治疗的依从性。症状包括疲劳、功能能力下降、肌肉萎缩和生活质量降低。让身体做好准备以耐受化疗等应激事件被称为“预康复”。本案例研究确定了在一名42岁新诊断的乳腺癌患者化疗前1周开始并持续8周进行有氧训练对疲劳和功能能力的疗效。该患者参加了一项有监督的居家步行计划。在运动训练前后，测量了日常活动中的疲劳程度和功能能力（12分钟步行、上下楼梯、从坐到站、从地面起身和站起、30秒二头肌卷曲）。结果表明，7项功能指标中有5项显示出改善，改善幅度在23.4%至54.5%之间。此外，日常生活活动中的疲劳以及完成功能任务后的疲劳都有所减轻。本案例研究的结果表明，在化疗前1周开始并在整个化疗期间持续进行有氧训练，可以减轻疲劳并提高功能能力。本案例研究提出了一种新方法，即在化疗前及化疗的8周期间引入运动，以减轻这种应激源的累积影响。
