Towfighi J, Gonatas N K, Pleasure D, Cooper H S, McCree L
Neurology. 1976 Mar;26(3):238-43. doi: 10.1212/wnl.26.3.238.
Progressive sensorimotor neuropathy developed in two patients exposed to prolonged (chronic) inhalation of n-hexane (glue sniffing). Sural nerve biopsies showed loss of axons; remaining axons were either normal or showed accumulation of filaments of 90 to 100 A thick, widened nodes of Ranvier, and focal enlargements. The muscle biopsy revealed neurogenic atrophy. Intramuscular nerve twigs and end-plates, studied in one patient, showed loss of axons and nerve terminals. Unmyelinated axons also showed accululation of 60 to 100 A thick filaments. The similarities between the pathologic findings in the peripheral nerve of these patients and those with acrylamide neuropathy suggest that the n-hexane inhalation produces a dying back neuropathy.
两名长期（慢性）吸入正己烷（吸胶）的患者出现了进行性感觉运动神经病。腓肠神经活检显示轴突丧失；剩余的轴突要么正常，要么显示有90至100埃厚的细丝堆积、郎飞结增宽和局灶性肿大。肌肉活检显示神经源性萎缩。在一名患者中研究的肌内神经小枝和终板显示轴突和神经末梢丧失。无髓鞘轴突也显示有60至100埃厚的细丝堆积。这些患者周围神经的病理发现与丙烯酰胺神经病患者的病理发现相似，提示吸入正己烷会导致轴索性神经病。
