Suzukia Yuka, Sano Nozomi, Shinonaga Chiya, Fukuda Mitsumasa, Hyodo Masamitsu, Morimoto Takehiko
Department of Pediatrics, Ehime University School of Medicine, Toon City, Japan.
Brain Dev. 2007 Nov;29(10):662-5. doi: 10.1016/j.braindev.2007.04.003. Epub 2007 May 25.
Prominent dysphagia is seen among patients with spinal muscular atrophy (SMA) type 2, especially at the late stage of their disease progression. Nasogastric tube feeding and gastrostomy are commonly utilized to maintain their nutritional status. However, choosing a treatment strategy to maintain appropriate nutritional status is often complicated by multiple factors, such as physical conditions and social aspects. We report a 21-year-old man with SMA type 2 who has been suffering from severe dysphagia. The findings at video-fluoroscopic swallow study (VSS) were consistent with a diagnosis of cricopharyngeal dysphagia. His dysphagia was successfully treated with percutaneous injection of botulinum toxin A (BTA) into the cricopharyngeal muscle. Our result demonstrates that administration of BTA is one of the effective treatment choices for dysphagia in SMA patients.
在2型脊髓性肌萎缩症（SMA）患者中可见明显的吞咽困难，尤其是在疾病进展的晚期。鼻胃管喂养和胃造口术通常用于维持他们的营养状况。然而，选择一种维持适当营养状况的治疗策略往往因多种因素而变得复杂，如身体状况和社会因素。我们报告一名患有2型SMA的21岁男性，他一直患有严重的吞咽困难。电视荧光吞咽造影检查（VSS）的结果与环咽肌吞咽困难的诊断一致。通过向环咽肌经皮注射肉毒杆菌毒素A（BTA）成功治疗了他的吞咽困难。我们的结果表明，注射BTA是SMA患者吞咽困难的有效治疗选择之一。
