Köseoglu Emel, Karaman Yahya
Erciyes University, Medicine Faculty, Neurology Department, Kayseri, Turkey.
Clin Biochem. 2007 Aug;40(12):859-63. doi: 10.1016/j.clinbiochem.2007.04.007. Epub 2007 Apr 27.
The aim of this study was to evaluate the relationship between homocysteine (Hcy), folate and vitamin B12 levels in vascular dementia (VaD) and Alzheimer Disease (AD) to elucidate if they had similar pathogenesis due to cerebrovascular injury.
Plasma Hcy and serum folate, vitamin B12 levels were studied 67 VaD, 51 AD and 40 healthy control subjects. Vascular risk factors in these groups were also considered.
The changes in the levels of Hcy, folate and vitamin B12 were found to be not related with vascular risk factors. In VaD, Hcy level was higher (p<0.001), folate and vitamin B12 levels were lower (p<0.05 for folate, p<0.001 for vitamin B12) than those in AD. Hcy level was negatively correlated with folate and vitamin B12 (p<0.05) in VaD but in AD. Hcy/folate and Hcy/vitamin B12 ratios were the highest in VaD.
The increase of Hcy in AD were seemed to be not related to cerebrovascular injury. It is possibly related to biochemical damages as result of oxidative stress.
本研究旨在评估血管性痴呆（VaD）和阿尔茨海默病（AD）中同型半胱氨酸（Hcy）、叶酸和维生素B12水平之间的关系，以阐明它们是否因脑血管损伤而具有相似的发病机制。
对67例VaD患者、51例AD患者和40例健康对照者的血浆Hcy以及血清叶酸、维生素B12水平进行了研究。还考虑了这些组中的血管危险因素。
发现Hcy、叶酸和维生素B12水平的变化与血管危险因素无关。在VaD中，Hcy水平较高（p<0.001），叶酸和维生素B12水平较低（叶酸p<0.05，维生素B12 p<0.001），与AD患者相比。在VaD中，Hcy水平与叶酸和维生素B12呈负相关（p<0.05），但在AD中并非如此。Hcy/叶酸和Hcy/维生素B12比值在VaD中最高。
AD中Hcy的升高似乎与脑血管损伤无关。它可能与氧化应激导致的生化损伤有关。
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