老年人认知障碍与血浆叶酸、维生素B12和同型半胱氨酸水平的关联。
Association of cognitive impairment with plasma levels of folate, vitamin B12 and homocysteine in the elderly.
作者信息
Dimopoulos Nikolaos, Piperi Christina, Salonicioti Aristea, Psarra Vassiliki, Gazi Flerri, Nounopoulos Charalambos, Lea Robert W, Kalofoutis Anastasios
机构信息
Department of Biological Chemistry, Medical School of Athens University 75 M. Asias St., Athens, Greece.
出版信息
In Vivo. 2006 Nov-Dec;20(6B):895-9.
BACKGROUND
Alterations in folate, vitamin B12 and homocysteine plasma levels have been associated with aging, neuronal development and cognitive impairment. The aim of this study was to investigate the relationship between plasma folate, vitamin B12 and homocysteine and cognitive function in the elderly.
PATIENTS AND METHODS
Elderly individuals over 60 years of age living in the community, were screened with the Mini-Mental State Examination. The study population was divided into two groups: (a) 37 subjects with dementia; and (b) 33 healthy controls. Blood samples were analyzed with the use of ELISA, and the results were statistically evaluated at p < 0.05 level of significance.
RESULTS
Group a had significantly lower levels of folate and vitamin B12 than group b. Homocysteine was significantly higher in demented individuals than in controls (p < 0.01).
CONCLUSION
Lower levels of plasma folate and/or vitamin B12 and higher levels of plasma homocysteine are associated with cognitive impairment in elderly individuals.
背景
血浆中叶酸、维生素B12和同型半胱氨酸水平的改变与衰老、神经元发育和认知障碍有关。本研究的目的是调查老年人血浆叶酸、维生素B12和同型半胱氨酸与认知功能之间的关系。
患者与方法
对居住在社区的60岁以上老年人进行简易精神状态检查表筛查。研究人群分为两组：（a）37名痴呆患者；（b）33名健康对照者。采用酶联免疫吸附测定法分析血样，并在p<0.05的显著性水平上对结果进行统计学评估。
结果
a组的叶酸和维生素B12水平显著低于b组。痴呆患者的同型半胱氨酸水平显著高于对照组（p<0.01）。
结论
老年人血浆叶酸和/或维生素B12水平较低以及血浆同型半胱氨酸水平较高与认知障碍有关。
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