Santambrogio L, Bellomo G, Mercuri M, Paltriccia R, Ciuffetti G, Mannarino E
Institute of Clinica Medica II, University of Perugia Medical School, Italy.
J Neural Transm Suppl. 1991;33:111-4. doi: 10.1007/978-3-7091-9135-4_17.
This study used digital photoplethysmography (d-FPG) to investigate alterations in skin blood flow after exposure to cold as well as the post-prandial blood pressure pattern to assess how the sympathetic branch of autonomic nervous system (ANS) functioned in 31 patients with cerebral dysautonomia and in 27 healthy controls. d-FPG was carried out on all ten fingers in basal conditions and after exposure to ice-cold water (4-5 degrees C). Amplitude, crest time and inclination time were used to calculate the alterations induced by the cold pressor test. After a standard lunch blood pressure was monitored every 20 minutes using a fully automatic non-invasive sphygmanometer. Unlike the controls the amplitude of the photoplethysmographic wave increased in all patients except 2; crest time and inclination time decreased in all except 3; post-prandial diastolic and systolic blood pressure levels fell markedly in all but 3. Blood vessel smooth muscle tone is disturbed in patients with ANS failure because dysautonomia may permit the action of vasodilating substances to predominate. The post-prandial blood pressure pattern and the d-FPG used in conjunction with a cold pressor test are useful tools in the non-invasive investigation of ANS function.
本研究采用数字光电容积脉搏波描记法（d-FPG），对31例脑自主神经功能障碍患者和27名健康对照者，研究暴露于寒冷环境后皮肤血流的变化以及餐后血压模式，以评估自主神经系统（ANS）的交感神经分支功能。在基础状态下以及暴露于冰水（4-5摄氏度）后，对所有十个手指进行d-FPG检测。使用振幅、波峰时间和倾斜时间来计算冷加压试验引起的变化。标准午餐后，使用全自动无创血压计每20分钟监测一次血压。与对照组不同，除2例患者外，所有患者光电容积脉搏波的振幅均增加；除3例患者外，波峰时间和倾斜时间均下降；除3例患者外，餐后舒张压和收缩压水平均明显下降。自主神经功能衰竭患者的血管平滑肌张力受到干扰，因为自主神经功能障碍可能使血管舒张物质的作用占主导地位。餐后血压模式以及与冷加压试验结合使用的d-FPG，是非侵入性研究自主神经功能的有用工具。
