Er Uygur, Kazanci Atilla, Eyriparmak Taner, Yigitkanli Kazim, Senveli Engin
Ministry of Health, Diskapi Education and Research Hospital, 2nd Neurosurgery Clinic, Diskapi 06510, Ankara, Turkey.
J Clin Neurosci. 2007 Jul;14(7):676-8. doi: 10.1016/j.jocn.2006.03.010.
Melanotic schwannomas are tumors of Schwann cell origin, characterized by cytoplasmic deposition of melanin. Melanotic schwannomas are rare. Description of the course of these tumors differs somewhat, but it is generally considered a benign lesion.
A 54-year-old man presented with hypoesthesia, pain and weakness of the right arm and leg for 4 months. An MRI scan revealed an intradural extramedullary lesion at the level of the foramen magnum and C1. OPERATION: Total resection of the mass was performed. A diagnosis of melanotic schwannoma was made based on histologic morphology and the immunohistochemical profile. Over a 2-year follow-up period there has been no local recurrence.
Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of Schwann cells. Distinguishing between this tumor and malignant melanoma is important in planning management. Total resection should be performed. Appropriate long-term follow-up is needed for all melanotic schwannomas.
黑色素性神经鞘瘤是起源于施万细胞的肿瘤，其特征为黑色素在细胞质内沉积。黑色素性神经鞘瘤较为罕见。关于这些肿瘤病程的描述略有不同，但一般认为是良性病变。
一名54岁男性因右臂和右腿感觉减退、疼痛及无力4个月就诊。磁共振成像（MRI）扫描显示在枕骨大孔和C1水平存在硬脊膜内髓外病变。
对肿块进行了全切除。根据组织形态学和免疫组化特征诊断为黑色素性神经鞘瘤。在2年的随访期内未出现局部复发。
黑色素性神经鞘瘤是神经鞘瘤的一种罕见变体，由具有施万细胞超微结构特征的产黑色素细胞组成。在制定治疗方案时，区分这种肿瘤与恶性黑色素瘤很重要。应进行全切除。所有黑色素性神经鞘瘤都需要进行适当的长期随访。
