Ulanowska Katarzyna, Piosik Jacek, Gwizdek-Wiśniewska Anna, Wegrzyn Grzegorz
Department of Molecular Biology, University of Gdańsk, Kładki 24, Gdańsk, Poland.
Bioorg Med Chem. 2007 Aug 1;15(15):5150-7. doi: 10.1016/j.bmc.2007.05.025. Epub 2007 May 17.
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin causing symptoms that resemble those observed in patients suffering from Parkinson's disease. However, in animal or human organisms, MPTP is converted to MPDP(+) (1-methyl-4-phenyl-2,3-dihydropyridinium) and further to MPP(+) (1-methyl-4-phenylpyridinium); the latter compound is the actual neurotoxin. In this report, we demonstrate that MPDP(+) and MPP(+) can form stacking complexes with methylxanthines (caffeine and penthoxifylline), which leads to significant impairment of the biological activity of these toxins (as measured by their mutagenicity).
MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）是一种神经毒素，其引发的症状与帕金森病患者所表现出的症状相似。然而，在动物或人体中，MPTP会转化为MPDP(+)（1-甲基-4-苯基-2,3-二氢吡啶鎓），并进一步转化为MPP(+)（1-甲基-4-苯基吡啶鎓）；后一种化合物才是真正的神经毒素。在本报告中，我们证明MPDP(+)和MPP(+)可与甲基黄嘌呤（咖啡因和己酮可可碱）形成堆积复合物，这会导致这些毒素的生物活性显著受损（以其诱变性衡量）。
