用于评估水溶性溶质与多组分包装材料之间相互作用的加和模型。

Additive model for the evaluation of interactions between aqueous solutes and multi-component container materials.

作者信息

Jenke D R

机构信息

Baxter Healthcare Corporation, William B. Graham Science Center, Round Lake, Illionis.

出版信息

J Parenter Sci Technol. 1991 Sep-Oct;45(5):233-8.

PMID:1753314

Abstract

The interaction between aqueous model solutes and various current or potential parenteral solution container materials was studied. Materials examined included composite polymers (plasticized PVC and co-extruded composites) and their individual components. For each material studied (component and composite), the equilibrium interaction constant (Eb), which describes the distribution of a solute between a container and its contained solution, can be related to the solute's octanol-water (Po-w) and hexane-water (Ph-w) partition coefficients via a bimodal Collander-type expression: log Eb = a log Po-w + b log Ph-w + c Additionally, the interaction of the composites was found to be equivalent to the weighted average of the interaction properties of its individual components. That is, Eb,composite = sigma Wi x Eb,i where i represents an individual component of the composite and Wi represents the weight fraction of that component in the composite. The impact of the interaction properties of the components on the behavior of the composites is discussed; thus, for example, the interaction properties exhibited by plasticized PVC is dominated by the behavior of the plasticizer since unplasticized PVC itself exhibits only minimal interaction with aqueous solutes.

摘要

研究了水性模型溶质与各种当前或潜在的肠胃外溶液容器材料之间的相互作用。所研究的材料包括复合聚合物（增塑聚氯乙烯和共挤出复合材料）及其各个组分。对于所研究的每种材料（组分和复合材料），描述溶质在容器与其所含溶液之间分布的平衡相互作用常数（Eb），可通过双峰科兰德型表达式与溶质的辛醇 - 水（Po-w）和己烷 - 水（Ph-w）分配系数相关联：log Eb = a log Po-w + b log Ph-w + c 此外，发现复合材料的相互作用等同于其各个组分相互作用特性的加权平均值。也就是说，Eb,复合材料 = ∑Wi × Eb,i，其中i代表复合材料的单个组分，Wi代表该组分在复合材料中的重量分数。讨论了组分的相互作用特性对复合材料行为的影响；因此，例如，增塑聚氯乙烯表现出的相互作用特性主要由增塑剂的行为决定，因为未增塑的聚氯乙烯本身与水性溶质的相互作用极小。