Lee W-K, Kao S-T, Liu I-M, Cheng J-T
Graduate School of Chinese Traditional Medicine, China Medical University, Taichung City, Taiwan, RO China.
Horm Metab Res. 2007 May;39(5):347-54. doi: 10.1055/s-2007-976537.
Ginsenoside Rh2, one of the ginsenosides contained in the Panax ginseng root, was employed to screen the effect on insulin resistance of rats induced by a diet containing 60% fructose. Single intravenous injection of ginsenoside Rh2 decreased the plasma glucose concentrations in 60 minutes in a dose-dependent manner from 0.1 mg/kg to 1 mg/kg in rats with insulin resistance induced by fructose-rich chow. Repeated intravenous injection of ginsenoside Rh2 (1 mg/kg per injection, 3 times daily) into rats which received fructose-rich chow for 3 consecutive days decreased the value of glucose-insulin index, the product of the areas under the curve of glucose and insulin during the intraperitoneal (i.p.) glucose tolerance test. This means that ginsenoside Rh2 has an ability to improve insulin action on glucose disposal. The plasma glucose lowering action of tolbutamide, induced by the secretion of endogenous insulin, is widely used to characterize the formation of insulin resistance. Time for the loss of plasma glucose lowering response to tolbutamide (10 mg/kg, i.p.) in rats during insulin resistance induction by fructose-rich chow was also markedly delayed by the repeated treatment of ginsenoside Rh2, as compared to the vehicle-treated control. Thus, the repeated treatment of ginsenoside Rh2 delayed the development of insulin resistance in high fructose feeding rats. Increase of insulin sensitivity by ginsenoside Rh2 was further identified using the plasma glucose lowering action of exogenous insulin in streptozotocin-induced diabetic rats (STZ-diabetic rats). Repeated injection of ginsenoside Rh2 at the same dosing (1 mg/kg, 3 times daily) into STZ-diabetic rats for 10 days made an increase of the responses to exogenous insulin. Taken together, it can be concluded that ginsenoside Rh2 has an ability to improve insulin sensitivity and it seems suitable to use ginsenoside Rh2 as an adjuvant for diabetic patients and/or the subjects wishing to increase insulin sensitivity.
人参皂苷Rh2是人参根中含有的一种人参皂苷，被用于研究其对由含60%果糖饮食诱导的大鼠胰岛素抵抗的影响。单次静脉注射人参皂苷Rh2能使果糖诱导胰岛素抵抗的大鼠在60分钟内以剂量依赖的方式降低血糖浓度，剂量范围从0.1mg/kg至1mg/kg。连续3天给喂食富含果糖食物的大鼠重复静脉注射人参皂苷Rh2（每次注射1mg/kg，每日3次），可降低葡萄糖-胰岛素指数，该指数是腹腔内葡萄糖耐量试验期间葡萄糖和胰岛素曲线下面积的乘积。这意味着人参皂苷Rh2具有改善胰岛素对葡萄糖处置作用的能力。甲苯磺丁脲通过内源性胰岛素分泌诱导的降低血糖作用，被广泛用于表征胰岛素抵抗的形成。与载体处理的对照组相比，在富含果糖饮食诱导胰岛素抵抗期间，人参皂苷Rh2的重复处理也显著延迟了大鼠对甲苯磺丁脲（10mg/kg，腹腔注射）降低血糖反应的消失时间。因此，人参皂苷Rh2的重复处理延缓了高果糖喂养大鼠胰岛素抵抗的发展。在链脲佐菌素诱导的糖尿病大鼠（STZ-糖尿病大鼠）中，通过外源性胰岛素降低血糖的作用进一步证实了人参皂苷Rh2可增加胰岛素敏感性。以相同剂量（1mg/kg，每日3次）给STZ-糖尿病大鼠重复注射人参皂苷Rh2 10天，可增强对外源性胰岛素的反应。综上所述，可以得出结论，人参皂苷Rh2具有改善胰岛素敏感性的能力，似乎适合将人参皂苷Rh2用作糖尿病患者和/或希望提高胰岛素敏感性的受试者的辅助药物。
Zotero 插件