Zafra-Stone Shirley, Yasmin Taharat, Bagchi Manashi, Chatterjee Archana, Vinson Joe A, Bagchi Debasis
Research and Development Department, InterHealth Research Center, Benicia, CA, USA.
Mol Nutr Food Res. 2007 Jun;51(6):675-83. doi: 10.1002/mnfr.200700002.
Edible berries, a potential source of natural anthocyanin antioxidants, have demonstrated a broad spectrum of biomedical functions. These include cardiovascular disorders, advancing age-induced oxidative stress, inflammatory responses, and diverse degenerative diseases. Berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. This chapter demonstrates the beneficial effects of wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry in human health and disease prevention. Furthermore, this chapter will discuss the pharmacological benefits of a novel combination of selected berry extracts known as OptiBerry, a combination of wild blueberry, wild bilberry, cranberry, elderberry, raspberry seeds, and strawberry, and its potential benefit over individual berries. Recent studies in our laboratories have demonstrated that OptiBerry exhibits high antioxidant efficacy as shown by its high oxygen radical absorbance capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic activities, and potential cytotoxicity towards Helicobacter pylori, a noxious pathogen responsible for various gastrointestinal disorders including duodenal ulcer and gastric cancer, as compared to individual berry extracts. OptiBerry also significantly inhibited basal MCP-1 and inducible NF-kappabeta transcriptions as well as the inflammatory biomarker IL-8, and significantly reduced the ability to form hemangioma and markedly decreased EOMA cell-induced tumor growth in an in vivo model. Overall, berry anthocyanins trigger genetic signaling in promoting human health and disease prevention.
可食用浆果作为天然花青素抗氧化剂的潜在来源，已展现出广泛的生物医学功能。这些功能包括心血管疾病、衰老引发的氧化应激、炎症反应以及各种退行性疾病。浆果中的花青素还能改善神经元和认知脑功能、眼部健康，并保护基因组DNA的完整性。本章阐述了野生蓝莓、欧洲越橘、蔓越莓、接骨木果、树莓籽和草莓对人类健康及疾病预防的有益作用。此外，本章还将讨论一种名为OptiBerry的精选浆果提取物新型组合的药理益处，OptiBerry是野生蓝莓、野生欧洲越橘、蔓越莓、接骨木果、树莓籽和草莓的组合，以及它相对于单一浆果的潜在优势。我们实验室最近的研究表明，与单一浆果提取物相比，OptiBerry具有高抗氧化功效，这体现在其高氧自由基吸收能力（ORAC）值上，还具有新型抗血管生成和抗动脉粥样硬化活性，以及对幽门螺杆菌（一种导致包括十二指肠溃疡和胃癌在内的各种胃肠道疾病的有害病原体）的潜在细胞毒性。OptiBerry还显著抑制基础MCP - 1和诱导型NF - κB的转录以及炎症生物标志物IL - 8，并在体内模型中显著降低形成血管瘤的能力以及明显减少EOMA细胞诱导的肿瘤生长。总体而言，浆果花青素在促进人类健康和疾病预防方面触发基因信号传导。
