Ogawa Kenji, Inui Toshio, Sugio Takeshi
Graduate School of Informatics, Kyoto University, Kyoto, Japan.
Cortex. 2007 Apr;43(3):289-300. doi: 10.1016/s0010-9452(08)70455-6.
State estimation of self-movement, based on both motor commands and sensory feedback, has been suggested as essential to human movement control to compensate for inherent feedback delays in sensorimotor loops. The present study investigated the neural basis for state estimation of human movement using event-related functional magnetic resonance imaging (fMRI). Participants traced visually presented curves with a computer mouse, and an artificial delay was introduced to visual feedback. Motor performance and brain activities during movements were measured. Experiment 1 investigated brain activations that were significantly correlated with visual feedback delay and motor error by parametrically manipulating visual feedback delay. Activation of the right posterior parietal cortex (PPC) was positively correlated with motor error, whereas activation of the right temporo-parietal junction (TPJ) was observed only in the group with a smaller increase in motor error with increased visual feedback delay. Experiment 2 involved parametric analysis of motor performance while controlling mouse movement speed during the task. Activity in the right TPJ showed a significant positive correlation with motor performance under the delayed visual feedback condition. In addition, activity of the PPC was greater when motor error was presented visually. These results suggest that the PPC plays a significant role in evaluating visuomotor prediction error, while the TPJ is involved in state estimation of self-movement during visually guided movements.
基于运动指令和感觉反馈的自我运动状态估计，被认为是人类运动控制中补偿感觉运动回路中固有反馈延迟所必需的。本研究使用事件相关功能磁共振成像（fMRI）来探究人类运动状态估计的神经基础。参与者用电脑鼠标追踪视觉呈现的曲线，并对视觉反馈引入人工延迟。测量运动过程中的运动表现和大脑活动。实验1通过参数化操纵视觉反馈延迟，研究了与视觉反馈延迟和运动误差显著相关的大脑激活情况。右侧后顶叶皮层（PPC）的激活与运动误差呈正相关，而右侧颞顶联合区（TPJ）的激活仅在随着视觉反馈延迟增加运动误差增加较小的组中观察到。实验2在任务期间控制鼠标移动速度时对运动表现进行参数分析。在延迟视觉反馈条件下，右侧TPJ的活动与运动表现呈显著正相关。此外，当视觉呈现运动误差时，PPC的活动更强。这些结果表明，PPC在评估视觉运动预测误差中起重要作用，而TPJ在视觉引导运动期间参与自我运动的状态估计。
