Imazu Sugiko, Sugio Takeshi, Tanaka Shigeki, Inui Toshio
Graduate School of Informatics, Kyoto University, Kyoto, Japan.
Cortex. 2007 Apr;43(3):301-7. doi: 10.1016/s0010-9452(08)70456-8.
We examined neural basis underlying tool-use behavior to discuss whether or not the usage of a well-learned tool has a specific route. Regional cerebral blood flow was measured in healthy Japanese subjects using functional magnetic resonance imaging (fMRI) during object pick-up using chopsticks, object pick-up using the hand, pantomiming the use of chopsticks, imagining the use of chopsticks, and imagining the use of the hand. First, the left inferior parietal lobule (IPL) was found to selectively contribute to tasks requiring explicit retrieval of tool-related hand movements that were pantomiming task and imagery task. This finding provides supporting evidence for the ideomotor apraxia (IMA) model proposed by Buxbaum (2001). However, departing from Buxbaum's (2001) proposal, the actual use of a well-learned tool displays distinct processing routes to those for pantomime and imagining. A comparison of these tasks revealed that activation in the lateral part of the right cerebellum increased during execution of tool-use, and this activity was considered to reflect the internal model for tools proposed by Imamizu et al. (2000, 2003).
我们研究了工具使用行为背后的神经基础，以探讨熟练掌握的工具的使用是否具有特定路径。在健康的日本受试者使用筷子拾取物体、用手拾取物体、模仿使用筷子、想象使用筷子以及想象用手的过程中，利用功能磁共振成像（fMRI）测量其局部脑血流量。首先，发现左侧下顶叶小叶（IPL）对需要明确检索与工具相关手部动作的任务有选择性贡献，这些任务包括模仿任务和想象任务。这一发现为布克斯鲍姆（2001年）提出的观念运动性失用症（IMA）模型提供了支持证据。然而，与布克斯鲍姆（2001年）的提议不同，熟练掌握的工具的实际使用显示出与模仿和想象不同的加工路径。对这些任务的比较表明，在工具使用执行过程中，右侧小脑外侧部分的激活增加，这种活动被认为反映了 Imamizu 等人（2000年、2003年）提出的工具内部模型。
