Coccia P, Ruggiero A, Attinà G, Lazzareschi I, Maurizi P, Riccardi R
Division of Pediatric Oncology, Policlinico A. Gemelli, Catholic University of Rome.
Pediatr Med Chir. 2006;28(4-6):73-8.
In pediatric oncology, LPs are frequently performed for diagnostic and therapeutic purposes. A LP procedure may be helpful in diagnosing many diseases and disorders. In addition, a LP may be performed therapeutically, to inject medications directly into the spinal canal. Intrathecal administration of antineoplastic drugs allows to bypass the selective filter of BBB and to achieve significant concentrations of the antineoplastic agents in CSF reducing the likelihood of systemic toxicity. Lumbar puncture is generally well tolerated but might be characterized by several disadvantages and risks.
在儿科肿瘤学中，腰椎穿刺（LP）常用于诊断和治疗目的。LP操作可能有助于诊断多种疾病和病症。此外，LP也可用于治疗，即将药物直接注入椎管。鞘内注射抗肿瘤药物可绕过血脑屏障的选择性滤过作用，使脑脊液中抗肿瘤药物达到有效浓度，从而降低全身毒性的可能性。腰椎穿刺一般耐受性良好，但也可能存在一些缺点和风险。
