Almanjomi Fahd, Armstrong Derek, Abla Oussama, Naqvi Ahmed, Weitzman Sheila, Hitzler Johann
Division of Haematology/Oncology, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.
Pediatr Blood Cancer. 2008 Aug;51(2):295-8. doi: 10.1002/pbc.21592.
Subdural fluid collections can interfere with the effective intrathecal administration of chemotherapy by lumbar puncture (LP). We detected this complication in six children who were treated for acute lymphoblastic leukemia (ALL) and presented with an elevated protein concentration of the cerebrospinal fluid (CSF) during routine LP. Contrary to expectation the lumbar fluid collections persisted in two cases and in one case required the insertion of an Ommaya reservoir to continue intrathecal chemotherapy. Awareness and detection of this complication by imaging is important because of its potential to interfere with effective CNS-directed chemotherapy of ALL.
硬膜下积液可能会干扰通过腰椎穿刺（LP）进行的鞘内化疗的有效给药。我们在6例接受急性淋巴细胞白血病（ALL）治疗的儿童中检测到了这种并发症，这些儿童在常规LP期间脑脊液（CSF）蛋白浓度升高。与预期相反，两例患者的腰段积液持续存在，一例患者需要插入Ommaya储液器以继续鞘内化疗。通过影像学认识和检测这种并发症很重要，因为它可能会干扰ALL有效的中枢神经系统定向化疗。
