Panegyres Peter K, Frencham Kate
Neurosciences Unit, Health Department of Western Australia, Perth.
Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):48-56. doi: 10.1177/1533317506295887.
The authors performed a prospective, unbiased analysis of a cohort of young patients assessed consecutively with the question of dementia. The onset of patients' cognitive symptoms was prior to the age of 65 years. A study group of 226 patients was followed for a mean duration of 4.59 +/- 2.23 years (1 SD; range, 0.04-7.86 years). The diagnoses were established using published diagnostic criteria. A diagnosis of dementia was made in 112 patients (49.56%). Psychiatric disease was the most common diagnosis in those who did not have dementia (24.3%) followed by frontotemporal lobar degeneration (19.0%), Alzheimer's disease (11.9%), patients with cognitive symptoms who obtained normal neuropsychometric profiles (10.6%), nonneurological disorders (eg, obstructive sleep apnea [8.4%]), neurological disorders (eg, Parkinson's disease [4.9%]), and mild cognitive impairment (4.9%). The frequencies of frontotemporal lobar degeneration and psychiatric disease were higher than Alzheimer's disease, unlike in older populations.
作者对一组因痴呆问题而连续接受评估的年轻患者进行了前瞻性、无偏倚分析。患者认知症状的出现早于65岁。对226名患者的研究组进行了平均4.59±2.23年（标准差1；范围0.04 - 7.86年）的随访。诊断依据已发表的诊断标准确定。112名患者（49.56%）被诊断为痴呆。在未患痴呆的患者中，精神疾病是最常见的诊断（24.3%），其次是额颞叶变性（19.0%）、阿尔茨海默病（11.9%）、神经心理测试结果正常但有认知症状的患者（10.6%）、非神经系统疾病（如阻塞性睡眠呼吸暂停[8.4%]）、神经系统疾病（如帕金森病[4.9%]）以及轻度认知障碍（4.9%）。与老年人群不同，额颞叶变性和精神疾病的发生率高于阿尔茨海默病。
