Sudo A, Fujinami S, Shiokawa Y, Ogihara Y
Department of Orthopaedic Surgery, Mie University School of Medicine, Tsu.
Jpn J Clin Oncol. 1991 Oct;21(5):346-52.
A retrospective study on chemotherapy against soft-tissue sarcomas in the extremities was carried out on 98 patients. The local recurrence rate was 10.3% with intensive chemotherapy in post-1980 patients with high-grade sarcomas but 46.7% without chemotherapy--a fairly significant difference (P less than 0.01). The survival rate was significantly higher with intensive chemotherapy in post-1980 patients with high-grade sarcomas. Thus, intensive chemotherapy based on a new protocol should be given in cases of high-grade sarcoma. Considering surgical margin, the local recurrence rate was 33.3% in post-1980 cases inadequately operated upon but 8.6% in those adequately operated upon, which shows a significant difference (P less than 0.05).
对98例肢体软组织肉瘤患者进行了化疗的回顾性研究。1980年后患有高级别肉瘤的患者，强化化疗后的局部复发率为10.3%，而未进行化疗的患者局部复发率为46.7%，差异相当显著（P<0.01）。1980年后患有高级别肉瘤的患者，强化化疗后的生存率显著更高。因此，对于高级别肉瘤病例，应采用基于新方案的强化化疗。考虑手术切缘，1980年后手术操作不充分的病例局部复发率为33.3%，而手术操作充分的病例局部复发率为8.6%，差异显著（P<0.05）。
