Suzuki A, Takahashi T, Taniguchi A, Kotake C, Seo T, Toda T, Kobayashi K, Tsukamoto N, Fukumoto M
Second Department of Internal Medicine, Faculty of Medicine, Kyoto University.
Jpn J Clin Oncol. 1991 Oct;21(5):384-7.
Pure red cell aplasia (PRCA) rarely occurs in non-thymic lymphoproliferative disorders. The present article describes a patient with non-Hodgkin's lymphoma (follicular, mixed type), who concurrently developed PRCA and warm type autoimmune hemolytic anemia during the clinical course. The PRCA and hemolytic anemia were successfully treated with prednisolone (60 mg/day). The patient died two years later, however, from advanced lymphoma without any recurrence of the PRCA or hemolytic anemia. To our knowledge, only 20 cases of PRCA associated with malignant lymphoma have been reported. The pathogeneses of the PRCA and hemolytic anemia in our patient are discussed.
纯红细胞再生障碍性贫血（PRCA）很少发生于非胸腺性淋巴增殖性疾病。本文描述了一名患有非霍奇金淋巴瘤（滤泡性，混合型）的患者，该患者在临床病程中同时并发了PRCA和温抗体型自身免疫性溶血性贫血。PRCA和溶血性贫血通过泼尼松龙（60毫克/天）成功治愈。然而，患者两年后死于晚期淋巴瘤，PRCA或溶血性贫血均未复发。据我们所知，仅有20例PRCA与恶性淋巴瘤相关的病例被报道。本文对我们这位患者PRCA和溶血性贫血的发病机制进行了讨论。
