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[慢性肾衰竭接受移植或透析患者的全髋关节置换术]

[Total hip arthroplasty in patients with chronic renal failure transplant or dialysis].

作者信息

Debarge R, Pibarot V, Guyen O, Vaz G, Carret J P, Bejui-Hugues J

机构信息

Service de Chirurgie Orthopédique et Traumatologique, Pavillon T, Hôpital Edouard Herriot, place Arsonval, 69003 Lyon.

出版信息

Rev Chir Orthop Reparatrice Appar Mot. 2007 May;93(3):222-7. doi: 10.1016/s0035-1040(07)90243-3.

Abstract

PURPOSE OF THE STUDY

Total hip arthroplasty (THA) is generally proposed for renal transplant patients with invalidating hip disease. For patients on chronic dialysis, the few published series report a higher rate of complications. These patients are considered more vulnerable. We report the results of a retrospective mid-term analysis of 28 renal failure patients (37 hips) with THA comparing renal transplant recipients with chronic dialysis patients.

MATERIAL AND METHODS

THA was performed on 37 hips in 28 patients with renal failure between January 1993 and 2004. Treatment for the renal disease was transplantation or chronic dialysis. Mean patient age at the time of the arthroplasty was 56 years. Nine patients had bilateral THA. At review, four patients had died and none were lost to follow-up. Mean time between transplantation and hip arthroplasty was 9.9 years. Among the fourteen dialysis patients (21 hips), five had had a renal transplant. Mean time from onset of dialysis to arthroplasty was 12.3 years. At mean postoperative follow-up of six years (range 24 months to 12 years), 24 patients were living. Thirty-five hips had no surgical history. Aseptic osteonecrosis was the dominant etiology (75% of operative indications in the graft group and 52% in the dialysis group). The preoperative Postel-Merle-d'Aubigné score was 7.6 in the dialysis group and 10.3 in the graft group. Most of the cups were not cemented (n=31, 84%), as were most of the stems (n=29, 78%). All survivors were reviewed. The PMA score was determined.

RESULTS

Early postoperative complications in the dialysis patients were: deep vein thrombosis (n=3), pulmonary embolism (n=4), operative site hematoma (n=2) and immediate septic complication with prompt revision and preservation of the implants (n=1). For the graft group, complications were: early dislocation (n=2), lung disease (n=3). Four patients, all in the dialysis group, died. At review, the mean PMA score was 14.2 in the dialysis patients and 15.7 in the graft patients. There were no radiological signs of loosening, nor of polyethylene wear, and no ectopic ossifications could be identified. There were no late infections.

DISCUSSION

In renal transplant recipients, total hip arthroplasty is a reliable treatment for hip disease, providing good mid-term results and a morbidity close to that observed in the general population. Conversely, dialysis patients have a greater perioperative morbidity. Use of non-cemented implants is not associated with a higher rate of loosening than with cemented implants. It can be recalled that this type of surgery must be performed within the framework of careful pluridisciplinary patient management.

摘要

研究目的

对于患有致残性髋关节疾病的肾移植患者,通常建议进行全髋关节置换术(THA)。对于接受慢性透析的患者,少数已发表的系列报道显示并发症发生率较高。这些患者被认为更易出现并发症。我们报告了对28例肾衰竭患者(37髋)进行THA的回顾性中期分析结果,比较了肾移植受者和慢性透析患者。

材料与方法

1993年1月至2004年期间,对28例肾衰竭患者的37髋进行了THA。肾病治疗方式为移植或慢性透析。关节置换术时患者的平均年龄为56岁。9例患者接受了双侧THA。复查时,4例患者死亡,无失访病例。移植与髋关节置换术之间的平均时间为9.9年。在14例透析患者(21髋)中,5例曾接受过肾移植。从透析开始到关节置换术的平均时间为12.3年。术后平均随访6年(范围24个月至12年),24例患者存活。35髋无手术史。无菌性骨坏死是主要病因(移植组手术指征的75%,透析组为52%)。透析组术前Postel-Merle-d'Aubigné评分为7.6,移植组为10.3。大多数髋臼杯未使用骨水泥固定(n = 31,84%),大多数股骨柄也是如此(n = 29,78%)。对所有存活患者进行了复查。确定了PMA评分。

结果

透析患者术后早期并发症包括:深静脉血栓形成(n = 3)、肺栓塞(n = 4)、手术部位血肿(n = 2)以及立即发生的感染性并发症并及时翻修且保留植入物(n = 1)。移植组的并发症包括:早期脱位(n = 2)、肺部疾病(n = 3)。4例患者死亡,均在透析组。复查时,透析患者的平均PMA评分为14.2,移植患者为15.7。没有松动的放射学迹象,也没有聚乙烯磨损,未发现异位骨化。没有晚期感染。

讨论

在肾移植受者中,全髋关节置换术是治疗髋关节疾病的可靠方法,中期效果良好,发病率与普通人群相近。相反,透析患者围手术期发病率更高。使用非骨水泥植入物与骨水泥植入物相比,松动率并不更高。可以回顾的是,这类手术必须在对患者进行仔细的多学科管理的框架内进行。

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