Rothuber Helfried, Kralovec Karl, Yazdi Kurosch, Plöderl Martin, Mitterauer Bernhard
University Clinic for Psychiatry and Psychotherapy, Christian Doppler Clinic, Salzburg, Austria.
Med Sci Monit. 2007 Jun;13(6):CR264-69.
A new model of depression is proposed which is biological and explanatory on the behavioral level. It is hypothesized that a patient suffering from a depressive disorder loses the ability to produce one or more modes of behavior at a given time and simultaneously has the urge to produce one or more other modes of behavior constantly. The patient is also unable to interpret his behavioral disorder ("loss of self-understanding").
MATERIAL/METHODS: The authors developed the Salzburg Subjective Behavioral Analysis (SSBA) self-assessment questionnaire asking subjects to elaborate on changes in 35 modes of behavior and to interpret the behavioral disorder, if possible. The study was conducted using this questionnaire and the Hamilton Depression Scale on 30 inpatients with depressive disorders and this questionnaire on 30 healthy controls.
Extreme positions in the SSBA were found in all 30 patients, compared with 2 in the 30 healthy controls. Significant correlation between the occurrence of extreme positions and the Hamilton scores was found (r=0.44, p=0.02) and correlation between the Hamilton scores and the inability of the patients to interpret the behavioral disorder was nearly significant (r=-0.35, p=0.06).
The occurrence of extreme positions in the SSBA increased with depressive mood. In addition, the likelihood that subjects could explain their extreme positions in behavior decreased with increasing depression. The SSBA questionnaire assesses the self-evaluation of modes of behavior. As a diagnostic instrument, DSM-IV does not have criteria for modes of behavior. Thus, behavioral analysis should be considered in diagnosing depression.
提出了一种新的抑郁症模型,该模型在行为层面具有生物学依据且能进行解释。据推测,患有抑郁症的患者在特定时间失去了产生一种或多种行为模式的能力,同时又不断有产生一种或多种其他行为模式的冲动。患者也无法解释自己的行为紊乱(“自我理解丧失”)。
材料/方法:作者编制了萨尔茨堡主观行为分析(SSBA)自评问卷,要求受试者详细阐述35种行为模式的变化,并尽可能解释行为紊乱情况。使用该问卷和汉密尔顿抑郁量表对30名抑郁症住院患者进行了研究,并用该问卷对30名健康对照者进行了研究。
在所有30名患者中均发现了SSBA中的极端情况,而30名健康对照者中只有2人出现这种情况。发现极端情况的出现与汉密尔顿评分之间存在显著相关性(r = 0.44,p = 0.02),并且汉密尔顿评分与患者无法解释行为紊乱之间的相关性接近显著(r = -0.35,p = 0.06)。
SSBA中极端情况的出现随抑郁情绪而增加。此外,随着抑郁程度的增加,受试者解释其极端行为的可能性降低。SSBA问卷评估行为模式的自我评估。作为一种诊断工具,《精神疾病诊断与统计手册》第四版(DSM-IV)没有行为模式的标准。因此,在诊断抑郁症时应考虑行为分析。