Watanabe T
First Department of Internal Medicine, Hiroshima University School of Medicine.
Nihon Ronen Igakkai Zasshi. 1991 Sep;28(5):646-56. doi: 10.3143/geriatrics.28.646.
The diurnal changes in postheparin lipolytic activity (PHLA) were studied as on aspect of its physiological changes in eight healthy volunteers in a fasting state. Serum lipids and PHLA in obese males were measured to determine the etiology of obesity-associated hypertriglyceridemia with respect to triglyceride (TG) catabolism. In the healthy nonobese volunteers, the lipoprotein lipase (LPL) activity did not show any diurnal changes, but decreased with time during fasting. The hepatic triglyceride lipase (HTGL) activity underwent diurnal changes, and was high in the morning and low at night. Perceiving the metabolic difference between young obese individuals (obese since childhood) and middle-aged obese individuals (obese since adulthood), PHLA and serum lipids were simultaneously determined and examined from the aspect of TG catabolism in a young male group aged 17-27 and an older male group aged 35-62. The lower-age group consisted of 15 normal-weight men and 25 obese men with 11 years (mean) of a history of obesity. The higher-age group consisted of 15 normal-weight men and 25 obese men with 12 years of a history of obesity. No differences were found in total cholesterol and LDL-cholesterol between the normal-weight and obese individuals of both groups. However, HDL-cholesterol was significantly decreased, only in the obese individuals of the higher age group, compared to the normal-weight individuals of this group. Serum TG and insulin were significantly higher in the obese individuals than normal-weight individuals of both groups. In the obese individuals in both groups, a positive correlation was demonstrated between serum TG and insulin. This suggested the increased production of TG in association with hypertriglyceridemia. In addition, TG positively correlated with LPL and HTGL activities in young obese individuals, while a negative correlation was demonstrated only between TG and LPL activity in older obese individuals. These results indicated an age-related difference in TG catabolism in obese individuals with obesity-associated hypertriglyceridemia.
在八名处于空腹状态的健康志愿者中，研究了肝素后脂解活性（PHLA）的昼夜变化，以此作为其生理变化的一个方面。测定肥胖男性的血脂和PHLA，以确定肥胖相关高甘油三酯血症在甘油三酯（TG）分解代谢方面的病因。在健康的非肥胖志愿者中，脂蛋白脂肪酶（LPL）活性未显示出任何昼夜变化，但在禁食期间随时间降低。肝甘油三酯脂肪酶（HTGL）活性呈现昼夜变化，早晨高而夜间低。考虑到年轻肥胖个体（自幼肥胖）和中年肥胖个体（成年后肥胖）之间的代谢差异，从TG分解代谢方面同时测定并检查了17至27岁年轻男性组和35至62岁老年男性组的PHLA和血脂。低年龄组由15名体重正常的男性和25名肥胖男性组成，肥胖病史平均为11年。高年龄组由15名体重正常的男性和25名肥胖男性组成，肥胖病史为12年。两组体重正常和肥胖个体之间的总胆固醇和低密度脂蛋白胆固醇没有差异。然而，与该组体重正常个体相比，仅在高年龄组的肥胖个体中，高密度脂蛋白胆固醇显著降低。两组肥胖个体的血清TG和胰岛素均显著高于体重正常个体。在两组肥胖个体中，血清TG与胰岛素之间呈正相关。这表明与高甘油三酯血症相关的TG生成增加。此外，年轻肥胖个体中TG与LPL和HTGL活性呈正相关，而老年肥胖个体中仅TG与LPL活性呈负相关。这些结果表明，在伴有肥胖相关高甘油三酯血症的肥胖个体中，TG分解代谢存在年龄相关差异。
