Doherty Bernadette, Rodriguez Virginia, Leslie Julian C, McClean Stephen, Smyth W Franklin
School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK.
Rapid Commun Mass Spectrom. 2007;21(13):2031-8. doi: 10.1002/rcm.3060.
A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information.
对五种常用精神活性药物（利培酮、舍曲林、帕罗西汀、曲米帕明和米氮平）及其代谢物的碰撞诱导解离进行了串联质谱研究。采用四极杆离子阱质谱法生成所研究化合物的串联质谱（MS/MS）数据，并用四极杆飞行时间质谱法辅助对产物离子进行结构归属。然后，这些裂解研究被用于开发一种液相色谱方法，以鉴定人毛发和唾液样本中的药物及其代谢物，从而提供相关的特征分析信息。
