Rozwadowski Z
Institute of Chemistry and Environmental Protection, Szczecin University of Technology, Al. Piastów 42, 70-065 Szczecin, Poland.
Magn Reson Chem. 2007 Jul;45(7):605-10. doi: 10.1002/mrc.2008.
The dirhodium method has been successfully applied in chiral recognition of the optically active Schiff bases, derivatives of ortho-hydroxyaldehydes existing in the NH-form. or at tautomeric equilibrium. The position of the equilibrium of Schiff bases as well as their adducts has been established on the basis of measurements of deuterium isotope effects on 13C chemical shifts. The presence of the proton transfer equilibrium or NH-tautomer has promoted the adduct formation. At the equilibrium state, formation of the adducts has shifted the proton transfer equilibrium towards the NH-form. The binding site was the oxygen atom of the proton donor group.
二铑方法已成功应用于对光学活性席夫碱的手性识别，这些席夫碱是存在于NH形式或处于互变异构平衡状态的邻羟基醛衍生物。席夫碱及其加合物的平衡位置已根据对13C化学位移的氘同位素效应测量确定。质子转移平衡或NH互变异构体的存在促进了加合物的形成。在平衡状态下，加合物的形成使质子转移平衡向NH形式移动。结合位点是质子供体基团的氧原子。
