Nakadate T, Kagawa J
Department of Hygiene and Public Health, Tokyo Women's Medical College, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Oct;29(10):1261-7.
In order to longitudinally study the pulmonary function development of children with a history of asthma, we measured the flow-volume curves of 441 fourth-grade children in seven primary schools randomly selected from the Kashima district in Ibaraki prefecture in 1980, and again in 1982 and 1984. Levels and slopes of pulmonary function indices for individual children were calculated in 325 children who performed acceptable forced expiratory maneuvers at all of the three surveys. In FVC and FEV1, no significant difference of levels and slopes was observed between children with asthmatic history and control children. However, the level and slope of V25 of children with asthmatic history were significantly lower than those of control children (0.5 l/sec for the level, 0.08 l/sec for the slope) even when only those who did not suffer from wheezing attack during the follow-up period were concerned. These results suggested that the functional change of peripheral airways in children with asthmatic history did not recover within a couple of years even when they were in remission. Moreover, the functional differences between those two groups of children might become larger in early adolescence.
为了纵向研究有哮喘病史儿童的肺功能发育情况，我们于1980年对茨城县鹿岛区随机选取的7所小学的441名四年级儿童测量了流量-容积曲线，并于1982年和1984年再次进行测量。在三次调查中均进行了可接受的用力呼气动作的325名儿童中，计算了个体儿童肺功能指标的水平和斜率。在用力肺活量（FVC）和第一秒用力呼气容积（FEV1）方面，有哮喘病史的儿童与对照儿童在水平和斜率上均未观察到显著差异。然而，即使仅考虑在随访期间未发生喘息发作的儿童，有哮喘病史儿童的25%肺活量时的流量（V25）水平和斜率也显著低于对照儿童（水平为0.5升/秒，斜率为0.08升/秒）。这些结果表明，有哮喘病史儿童的外周气道功能变化即使在缓解期也不会在几年内恢复。此外，这两组儿童之间的功能差异在青春期早期可能会变得更大。
