Kon Y, Konno A, Hashimoto Y, Endoh D
Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Anat Histol Embryol. 2007 Jun;36(3):172-8. doi: 10.1111/j.1439-0264.2006.00728.x.
In MRL mice aged more than 1 year, but not in C57BL/6 mice, ovaries had grossly visible cysts presenting unilaterally or bilaterally. Postnatally, all MRL mice developed ovarian cysts by 8 months of age. Observations by light microscopy, including lectin histochemistry, indicated that the cysts sometimes included papillomatous tissues located at the hilar region and were similar to the rete ovarii system, but not to follicles. Two types of epithelial cells, ciliated and non-ciliated, were arranged on the cysts, in which both cell types had many microvilli projecting in various directions and random ramifications in the cystic lumen. These characteristics suggest that ovarian cysts developing in MRL mice originate mostly from the rete ovarii. Cysts derived from the rete ovarii at 8 months of age were histologically detected in all C3H mice as well as MRL mice, with variable incidence in ICR, AKR, CBA/N and ddY, and none in C57L/6, DBA/2, BALB and A/J mice. However, measurement of the maximum diameters of the ovarian cysts indicated that MRL mice regularly possessed the largest cysts visible to the naked eye. This is the first report of ovarian cysts in this inbred strain, suggesting that ovarian cysts in MRL mice appear with stable incidence and development.
在1岁以上的MRL小鼠中，卵巢单侧或双侧出现肉眼可见的囊肿，但C57BL/6小鼠中未出现这种情况。出生后，所有MRL小鼠在8个月大时都会出现卵巢囊肿。通过光学显微镜观察，包括凝集素组织化学观察，发现囊肿有时包含位于门区的乳头状组织，类似于卵巢网系统，但与卵泡不同。囊肿上排列着两种上皮细胞，即纤毛上皮细胞和非纤毛上皮细胞，这两种细胞类型都有许多向不同方向突出的微绒毛，并且在囊腔内有随机分支。这些特征表明，MRL小鼠中发育的卵巢囊肿主要起源于卵巢网。在8个月大时，所有C3H小鼠以及MRL小鼠中都能通过组织学检测到源自卵巢网的囊肿，ICR、AKR、CBA/N和ddY小鼠中的发生率各不相同，而C57L/6、DBA/2、BALB和A/J小鼠中则未检测到。然而，对卵巢囊肿最大直径的测量表明，MRL小鼠通常拥有肉眼可见的最大囊肿。这是关于这种近交系小鼠卵巢囊肿的首次报道，表明MRL小鼠中的卵巢囊肿以稳定的发生率和发展情况出现。
