Nagai A, Sakamoto K, Takizawa T, Morinobu S, Yamano Y, Nagao N, Ishihara Y, Kagawa J
First Department of Medicine, Tokyo Women's Medical College. 2
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Aug;29(8):993-7.
We examined the airway injury of the guinea pig exposed to sulfuric acid submicron aerosols (1 mg/m3). The animals were exposed to filtered air (sham control) or to submicrometer-sized sulfuric acid aerosols for 4 hr/day, 6 days/week, with sacrifices after 4 hours, 3 days, 1, 2, and 4 weeks of acid exposure. Light and electron microscopic examinations revealed that epithelial injury such as disappearance of cilia in the central airways was observed and the severity of the injury increased with exposure duration. This experimental study shows that submicrometer particles of sulfuric acid induces significant alterations in the central airways and may be involved in the incidence of asthma attack.
我们研究了暴露于硫酸亚微米气溶胶（1毫克/立方米）的豚鼠气道损伤情况。将动物暴露于过滤空气（假对照）或亚微米级硫酸气溶胶中，每天4小时，每周6天，在酸暴露4小时、3天、1周、2周和4周后进行处死。光镜和电镜检查显示，在中央气道观察到上皮损伤，如纤毛消失，且损伤严重程度随暴露时间增加。这项实验研究表明，硫酸亚微米颗粒会引起中央气道的显著改变，可能与哮喘发作的发生率有关。
