肌萎缩侧索硬化症中远端运动潜伏期与复合肌肉动作电位之间的相关性
Correlation between distal motor latency and compound muscle action potential in amyotrophic lateral sclerosis.
作者信息
Mohammadi Bahram, Krampfl Klaus, Kollewe Katja, Seyfadini Amir, Bufler Johannes, Dengler Reinhard
机构信息
Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Hannover, Germany.
出版信息
Neurol Res. 2007 Jul;29(5):425-8. doi: 10.1179/016164107X159261.
OBJECTIVES
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other possible causes of progressive muscle wasting. However, there are also pathologic changes in nerve conduction studies in ALS patients.
METHODS
In this study we analysed the values of distal motor latency (DML), compound muscle action potential (CMAP) and motor nerve conduction velocity (MNCV) in 95 patients with definite ALS.
RESULTS
We found slight slowing of MNCV and moderate to strong reduction of CMAP and a prolongation of DML. We found no significant correlation between MNCV and CMAP.
DISCUSSION
The main finding of the present work was the negative correlation between DML and CMAP. It is interpreted as a very distal axonal damage as the main reason for prolongation of DML in ALS patients.
目的
肌萎缩侧索硬化症（ALS）是一种致命的神经退行性疾病，其特征为运动系统进行性选择性退化。肌电图对于ALS的诊断至关重要。测量周围神经的运动传导对于识别进行性肌肉萎缩的其他可能原因至关重要。然而，ALS患者的神经传导研究中也存在病理变化。
方法
在本研究中，我们分析了95例确诊为ALS患者的远端运动潜伏期（DML）、复合肌肉动作电位（CMAP）和运动神经传导速度（MNCV）值。
结果
我们发现MNCV略有减慢，CMAP中度至重度降低，DML延长。我们发现MNCV与CMAP之间无显著相关性。
讨论
本研究的主要发现是DML与CMAP之间呈负相关。这被解释为非常远端的轴突损伤是ALS患者DML延长的主要原因。
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