[Clinical analysis of infectious complications following abdominal cluster transplantation].
作者信息
Chen Hui-xing, Yin Lu, Peng Cheng-hong, Zhou Guang-wen, Shen Bai-yong, Chen Gui-ming, Chen Chun-qiu, Zhou Hui-jiang, Li Hong-wei
机构信息
Department of General Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2007 Mar 1;45(5):319-22.
OBJECTIVE
To investigate the characteristic and management of postoperative infection in abdominal cluster transplantation.
METHODS
Preliminary experience of two cases of abdominal cluster transplantation including small intestine was reviewed.
RESULTS
Combination of five immunosuppressive agents based on tacrolimus was used. Severe Gram-negative bacillus infections occurred. The majority of invasive fungal infections was due to Candida species. Cytomegalovirus (CMV) infection increased monocytes and caused eosinopenia and an inversion of the CD4(+) to CD8(+) cell ratio in recipient I, and human CMV matrix proteins pp71 (CMV-pp71) was detected and identified in bile by PCR. Microabscesses in liver transplant biopsies were presented.
CONCLUSIONS
Infectious complications after cluster transplantation were complicated. Strategies to optimize the immunity suppression protocol and early diagnosis and treatment will be important to reduce infection after abdominal cluster transplantation.
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