[Clinical analysis of infectious complications following abdominal cluster transplantation].

OBJECTIVE

To investigate the characteristic and management of postoperative infection in abdominal cluster transplantation.

METHODS

Preliminary experience of two cases of abdominal cluster transplantation including small intestine was reviewed.

RESULTS

Combination of five immunosuppressive agents based on tacrolimus was used. Severe Gram-negative bacillus infections occurred. The majority of invasive fungal infections was due to Candida species. Cytomegalovirus (CMV) infection increased monocytes and caused eosinopenia and an inversion of the CD4(+) to CD8(+) cell ratio in recipient I, and human CMV matrix proteins pp71 (CMV-pp71) was detected and identified in bile by PCR. Microabscesses in liver transplant biopsies were presented.

CONCLUSIONS

Infectious complications after cluster transplantation were complicated. Strategies to optimize the immunity suppression protocol and early diagnosis and treatment will be important to reduce infection after abdominal cluster transplantation.