Loriot Yohann, Fizazi Karim
Institut Gustave Roussy, 39 rue Camille-Desmoulins, 94800 Villejuif.
Bull Cancer. 2007 May;94(5):439-48.
Testicular germ-cell cancer is the most frequent malignancy in young men. In 80% of case no metastasis is observed at diagnosis. Orchidectomy is the initial therapeutic intervention. In case of a pure seminoma, three treatment options should be discussed after surgery : radiotherapy with a limited dose and volume, surveillance, and chemotherapy by single-agent carboplatin. In non-seminomatous germ cell tumour three options should also be considered : surveillance, chemotherapy (two cycles of the BEP regimen) or retroperitoneal lymph node dissection. The strategy should be chosen taking into account predictive factors of relapse and the patient willing. Whatever the strategy, the cure rate is about 99%.
睾丸生殖细胞癌是年轻男性中最常见的恶性肿瘤。80%的病例在诊断时未观察到转移。睾丸切除术是初始治疗干预措施。对于纯精原细胞瘤，术后应讨论三种治疗选择：有限剂量和体积的放射治疗、监测以及单药卡铂化疗。对于非精原细胞瘤性生殖细胞肿瘤，也应考虑三种选择：监测、化疗（BEP方案两个周期）或腹膜后淋巴结清扫术。应根据复发的预测因素和患者意愿选择治疗策略。无论采用何种策略，治愈率约为99%。
