[他克莫司对小鼠毛囊生长周期的影响]
[Effect of tacrolimus on the growth cycle of murine hair follicles].
作者信息
Tian Ting, Fan Wei-Xin, Dai Ye-Qin, Liu Li-Ping
机构信息
Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Apr;29(2):209-12.
OBJECTIVE
To explore the effect of tacrolimus on murine hair follicle cycle.
METHOD
Hematoxylin-eosin dyeing and reverse transcription-polymerase chain raction techniques were used.
RESULTS
Five days after depilation, the hair follicles in both the tacrolimus group and the minoxidil group was in anagen V, while that in the vaseline group was in anagen III. vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) were detected in back skin in both the tacrolimus group and the minoxidil group, but not in the vaseline group.
CONCLUSION
Tacrolimus can promote the growth of hair by stimulating the hair follicle to enter anagen V in mice, which may be explained by the effects of VEGF and HGF.
目的
探讨他克莫司对小鼠毛囊周期的影响。
方法
采用苏木精-伊红染色及逆转录-聚合酶链反应技术。
结果
脱毛后5天，他克莫司组和米诺地尔组的毛囊均处于生长期V期，而凡士林组处于生长期III期。他克莫司组和米诺地尔组的背部皮肤均检测到血管内皮生长因子（VEGF）和肝细胞生长因子（HGF），而凡士林组未检测到。
结论
他克莫司可通过刺激小鼠毛囊进入生长期V期促进毛发生长，这可能与VEGF和HGF的作用有关。
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