Zhang Ru-Zhi, Zhu Wen-Yuan
Department of Dermatology, Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Apr;29(2):268-71.
Melanoblasts, the precursors to melanocytes, originate in the neural crest. Some melanoblasts can travel to the hair follicle and further differentiate into pigment melanin-producing melanocytes. Hair follicles contain a pool of undifferentiated melanocyte stem cells (MSCs), which are sources of differentiated melanocytes, and functional melanocytes exhist in the hair bulb. The volume, life, and activity of melanocytes in a hair follicle is closely related with the growth cycle of follicle. Appearance of gray hair gray results from incomplete MSCs maintenance.
黑素母细胞是黑素细胞的前体，起源于神经嵴。一些黑素母细胞可迁移至毛囊并进一步分化为产生色素黑色素的黑素细胞。毛囊包含一群未分化的黑素细胞干细胞（MSCs），它们是分化黑素细胞的来源，功能性黑素细胞存在于毛球中。毛囊中黑素细胞的数量、寿命和活性与毛囊的生长周期密切相关。白发的出现是由于黑素细胞干细胞维持不完全所致。
