Kowala-Piaskowska Arleta
III Katedra Pediatrii, Klinika Chorób Zakaźnych i Neurologii, Dzieciecej Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu.
Postepy Biochem. 2006;52(4):399-407.
Genetic material of HCV consists of single-strained RNA. Generation of HCV mutants insensitive to the immune system activity and resistant to used medications seem to be a consequence of HCV genetic variability, unusual replication potential and selection pressure of the host organism. During only one day 10(12) of viral particles may be formed, many of which contain mutations. Selection pressure put by the immune system and used medications lead to the selection of new HCV variants insensitive to therapeutics. The aim of the study is to draw attention (by means of discussing the structure and replication of HCV) to therapeutical problems of chronic hepatitis C consisting of the biology of the virus. Clinical and laboratory factors dependent on the patient (e.g. biochemical, histopathological, genotype) were omitted.
丙型肝炎病毒（HCV）的遗传物质由单链RNA组成。HCV突变体的产生对免疫系统活性不敏感且对所用药物具有抗性，这似乎是HCV基因变异性、异常复制潜力以及宿主生物体选择压力的结果。在仅仅一天的时间里，可能会形成10¹²个病毒颗粒，其中许多都含有突变。免疫系统和所用药物施加的选择压力导致了对治疗不敏感的新HCV变体的产生。本研究的目的是（通过讨论HCV的结构和复制）引起人们对由病毒生物学构成的慢性丙型肝炎治疗问题的关注。依赖于患者的临床和实验室因素（如生化、组织病理学、基因型）被省略。
