Sahinarslan Asife, Guz Galip, Okyay Kaan, Torer Nihan, Bali Musa, Sindel Sükrü, Cengel Atiye
Department of Cardiology, Gazi University Medical School, Ankara, Turkey.
Acta Cardiol. 2007 Apr;62(2):171-6. doi: 10.2143/AC.62.2.2020238.
In patients with chronic renal failure, the main cause of mortality is cardiovascular disease. Cardiac troponin T (cTnT) and brain natriuretic peptide (BNP) are found to be related with decreased survival in both the normal population and in patients with chronic renal failure in different studies. Our aim is to investigate the relationship between cTnT and BNP in patients with chronic renal failure.
58 chronic haemodialysis patients were enrolled prospectively for the study. Blood samples for measurement of cTnT and BNP were collected after the haemodialysis. The patients are divided into 3 groups according to cTnT measurements. Group I included the patients with cTnT < 0.05 ng/ml, Group II included the patients with cTnT between 0.05 and 0.1 ng/ml and group III included the patients with cTnT > 0. 1 ng/ml. We performed echocardiography in all patients to measure the left ventricular ejection fraction and thickness of septum and posterior wall. When BNP levels were compared among the 3 groups, we found that the BNP level was lowest in group I and highest in group III (165.13 +/- 125.44 pg/dl; 236.0 +/- 107.83 pg/dl; 280.71 +/- 153.25 pg/dl, respectively) (P = 0.01).The difference in BNP levels among groups was statistically significant and independent from left ventricular hypertrophy, left ventricular ejection fraction and volume overload in multiple regression analysis. We also searched the relationship between plasma cTnT and BNP levels and found a positive correlation (r = 0.3; P = 0.023).
cTnT and BNP levels were related to each other in patients with chronic renal failure.These parameters can help to identify the patients with a high risk for cardiovascular diseases.
在慢性肾衰竭患者中，主要死亡原因是心血管疾病。在不同研究中发现，心肌肌钙蛋白T（cTnT）和脑钠肽（BNP）与正常人群及慢性肾衰竭患者的生存率降低有关。我们的目的是研究慢性肾衰竭患者中cTnT与BNP之间的关系。
前瞻性纳入58例慢性血液透析患者进行研究。血液透析后采集用于检测cTnT和BNP的血样。根据cTnT检测结果将患者分为3组。第一组包括cTnT<0.05 ng/ml的患者，第二组包括cTnT在0.05至0.1 ng/ml之间的患者，第三组包括cTnT>0.1 ng/ml的患者。我们对所有患者进行超声心动图检查以测量左心室射血分数以及室间隔和后壁厚度。当比较3组之间的BNP水平时，我们发现第一组BNP水平最低，第三组最高（分别为165.13±125.44 pg/dl；236.0±107.83 pg/dl；280.71±153.25 pg/dl）（P = 0.01）。在多元回归分析中，组间BNP水平差异具有统计学意义，且独立于左心室肥厚、左心室射血分数和容量超负荷。我们还研究了血浆cTnT与BNP水平之间的关系，发现呈正相关（r = 0.3；P = 0.023）。
慢性肾衰竭患者中cTnT和BNP水平相互关联。这些参数有助于识别心血管疾病高危患者。
