Tani Kousuke, Behenna Douglas C, McFadden Ryan M, Stoltz Brian M
The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Org Lett. 2007 Jun 21;9(13):2529-31. doi: 10.1021/ol070884s. Epub 2007 May 31.
The copper(I) iodide catalyzed phosphine/aryl halide coupling procedure of Buchwald et al. provides modular, robust, and scaleable access to phosphinooxazoline (PHOX) ligands. The advantages of this method are highlighted by the convenient synthesis of PHOX ligands with varied steric and electronic properties, which would be challenging to synthesize by other protocols.
布赫瓦尔德等人的碘化亚铜催化的膦/芳基卤化物偶联方法，为膦基恶唑啉（PHOX）配体提供了模块化、稳健且可扩展的合成途径。通过该方法能够方便地合成具有不同空间和电子性质的PHOX配体，凸显了此方法的优势，而这些配体用其他方法合成具有挑战性。
