Fan Y M, Lehtimäki T, Rontu R, Ilveskoski E, Goebeler S, Kajander O, Mikkelsson J, Viiri L E, Perola M, Karhunen P J
Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Finland.
Eur J Clin Invest. 2007 Jun;37(6):472-7. doi: 10.1111/j.1365-2362.2007.01812.x.
The T allele of the hepatic lipase (HL) C-480T polymorphism was previously found to be associated with lower post-heparin plasma HL activity, atherosclerosis and risk of coronary artery disease. We studied the association of HL C-480T polymorphism with the extent of atherosclerosis at vessel-wall level in an autopsy series of middle-aged men.
An autopsy cohort of 700 Caucasian Finnish men aged 33-70 years (mean 53 years), which comprised two autopsy series, collected 10 years apart during 1981-82 and 1991-92, were analysed. Areas of coronary wall covered with fatty streaks and fibrotic and complicated lesions were measured using computer-assisted planimetry and related to HL C-480T genotypes (CC, CT, and TT).
There was a significant age-by-genotype interaction on the mean percentage area of fatty streaks (P = 0.01). The HL C-480T polymorphism was a significant explanatory factor for fatty streak area in men under 53 years of age with or without age, body mass index, hypertension, diabetes, smoking, alcohol consumption, apolipoprotein E genotype, and series number as covariates. Men carrying the TT genotype had two times larger areas of fatty streaks compared to the CC carriers (8.8% vs. 4.3%, P = 0.009). However, this association disappeared in men over 53 years. The areas of more advanced atherosclerotic lesions did not vary significantly among the genotype groups.
Our results suggest that the HL C-480T polymorphism affects the formation of early coronary atherosclerotic lesions in men in their early middle age.
先前发现肝脂酶（HL）C-480T多态性的T等位基因与肝素后血浆HL活性降低、动脉粥样硬化及冠状动脉疾病风险相关。我们在一个中年男性尸检系列中研究了HL C-480T多态性与血管壁水平动脉粥样硬化程度的关联。
分析了一个由700名年龄在33至70岁（平均53岁）的芬兰白人男性组成的尸检队列，该队列包括两个尸检系列，分别在1981 - 1982年和1991 - 1992年相隔10年收集。使用计算机辅助平面测量法测量冠状动脉壁上覆盖脂肪条纹、纤维化和复杂病变的面积，并将其与HL C-480T基因型（CC、CT和TT）相关联。
在脂肪条纹的平均面积百分比上存在显著的年龄与基因型交互作用（P = 0.01）。以年龄、体重指数、高血压、糖尿病、吸烟、饮酒、载脂蛋白E基因型和系列编号作为协变量，HL C-480T多态性是53岁及以下男性脂肪条纹面积的一个显著解释因素。携带TT基因型的男性与携带CC基因型的男性相比，脂肪条纹面积大两倍（8.8%对4.3%，P = 0.009）。然而，这种关联在53岁以上男性中消失。在基因型组之间，更晚期动脉粥样硬化病变的面积没有显著差异。
我们的结果表明，HL C-480T多态性影响中年早期男性早期冠状动脉粥样硬化病变的形成。
