年龄对凝血酶原G20210A突变导致自发性静脉血栓形成风险的影响。

The influence of the age in the risk of the prothrombin G20210A mutation for spontaneous venous thrombosis.

作者信息

Gutiérrez Tous María Reyes, Couto Caro Carmen, García-Donas Gabaldón Gloria, Viloria Peñas María del Mar, Simón Pilo Isabel, Almeida González Carmen

机构信息

Department of Hematology, The Valme University Hospital, Seville, Spain.

出版信息

Med Clin (Barc). 2007 May 5;128(17):652-4. doi: 10.1157/13102051.

DOI:10.1157/13102051

PMID:17537362

Abstract

BACKGROUND AND OBJECTIVE

Factor V Leiden mutation (FVL), and the prothrombin G20210A mutation (PT G20210A) are polymorphisms with a weak risk factor for venous thromboembolic disease. The probability of spontaneous venous thrombosis in carriers of thrombophilic mutations (FVL and PT G20210A) was analyzed.

PATIENTS AND METHOD

We studied 735 individuals (407 were healthy controls and 328 patients with venous thrombosis) with respect to FVL and PT G20210A, determined by polimerase chain reaction in liquid phase, real time. chi2 test and logistic regression analysis were used to evaluate the results. The dates were analyzed with the statistical program SPSS v. 14.0.

RESULTS

The carrier patients of PT G20210A mutation whose age was over 40 years had a risk factor for spontaneous venous thrombosis which was 9.28 (odds ratio [OR]) (95% confidence interval [CI], 3.01-28.60; p < 0.0005) times greater than carriers of the PT G20210A mutation who were 40 year-old or younger. In our patients, being male meant a weak risk factor for venous spontaneous thrombosis (p = 0.021; OR = 1.64; 95% CI, 1.08-2.51) .

CONCLUSIONS

Our results demonstrate a potentiation of the thrombotic risk by an increase of age in the carriers of the PT G20210A mutation.

摘要

背景与目的

凝血因子V莱顿突变（FVL）和凝血酶原G20210A突变（PT G20210A）是静脉血栓栓塞性疾病风险因素较弱的多态性。分析了血栓形成倾向突变携带者（FVL和PT G20210A）发生自发性静脉血栓形成的概率。

患者与方法

我们研究了735例个体（407例为健康对照，328例为静脉血栓形成患者）的FVL和PT G20210A，通过液相实时聚合酶链反应进行测定。采用卡方检验和逻辑回归分析来评估结果。数据用统计软件SPSS v. 14.0进行分析。

结果

年龄超过40岁的PT G20210A突变携带者发生自发性静脉血栓形成的风险因素是40岁及以下PT G20210A突变携带者的9.28倍（优势比[OR]）（95%置信区间[CI]，3.01 - 28.60；p < 0.0005）。在我们的患者中，男性是静脉自发性血栓形成的一个较弱风险因素（p = 0.021；OR = 1.64；95% CI，1.08 - 2.51）。