瞬态前驱体策略还是非常小的生物磷灰石晶体？

Transient precursor strategy or very small biological apatite crystals?

作者信息

Grynpas Marc D, Omelon Sidney

出版信息

Bone. 2007 Aug;41(2):162-4. doi: 10.1016/j.bone.2007.04.176. Epub 2007 Apr 21.

DOI:10.1016/j.bone.2007.04.176

Abstract

The mechanisms of skeletal mineralization have been studied and debated for decades. Recent Raman spectroscopic identification of octacalcium phosphate-like phosphate ions and possibly amorphous calcium phosphate ions in nascent bone mineral were claimed to support a transient precursor strategy for bone apatite formation. However, this data does not refute the theory that the newest, detectable bone mineral is very small, poorly crystalline biological apatite, because non-apatitic phosphate species have previously been identified in biological apatite and detected on the surfaces of nano-sized hydroxyapatite crystals.

摘要

骨骼矿化机制已被研究和争论了数十年。最近，通过拉曼光谱法鉴定出新生骨矿物质中存在类似磷酸八钙的磷酸根离子以及可能存在的无定形磷酸钙离子，这被认为支持了骨磷灰石形成的瞬态前体策略。然而，这些数据并未反驳以下理论：最新的、可检测到的骨矿物质是非常小的、结晶性差的生物磷灰石，因为此前已在生物磷灰石中鉴定出非磷灰石类磷酸盐物种，并在纳米级羟基磷灰石晶体表面检测到它们。