孕酮在兔输卵管和子宫中的结合

Progesterone binding in rabbit oviduct and uterus.

作者信息

Muechler E K, Flickinger G L, Mastroianni L, Mikhail G

出版信息

Proc Soc Exp Biol Med. 1976 Feb;151(2):275-9. doi: 10.3181/00379727-151-39191.

Abstract

Progesterone binding of high affinity with a dissociation constant of 10(-9) M was identified in cytosol of rabbit oviduct and uterus. Macromolecules with sedimentation coefficients of 7-8 S and 4-5 S were present. Progesterone receptor concentration was two to fivefold lower in the oviduct when compared with the uterus. The receptor concentration declined steadily from 3 hr until 144 hr after mating in the uterus; however, the decline in oviductal receptor was not significant until the sixth day of pregnancy. Progesterone receptor concentration in rabbit oviduct and uterus in estrus and early pregnancy was greater than estradiol receptor levels.

摘要

在兔输卵管和子宫的胞质溶胶中鉴定出了与孕酮具有高亲和力、解离常数为10（-9）M的结合。存在沉降系数为7 - 8 S和4 - 5 S的大分子。与子宫相比，输卵管中的孕酮受体浓度低两到五倍。在子宫中，交配后3小时到144小时，受体浓度稳步下降；然而，输卵管受体在怀孕第六天之前下降不明显。发情期和怀孕早期兔输卵管和子宫中的孕酮受体浓度高于雌二醇受体水平。