Sugaya E, Ishige A, Sekiguchi K, Yuzurihara T, Iizuka S, Sugimoto A, Takeda S, Wakui Y, Ishihara K, Aburada M
Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
J Ethnopharmacol. 1991 Aug;34(1):13-9. doi: 10.1016/0378-8741(91)90184-f.
In the cobalt focus experimental epilepsy model, severe hippocampal neuron damage occurs with marked EEG changes. The effects of TJ-960, a herbal medicine formulation, were studied on neuron damage in the CA1 area of rat hippocampus. Continuous oral administration of TJ-960 from one month prior to the cobalt application showed almost complete protection against hippocampal neuron damage induced by cobalt application to the cerebral cortex. TJ-960 also completely inhibited the EEG changes as well as the brain edema induced by cobalt application.
在钴聚焦实验性癫痫模型中，会出现严重的海马神经元损伤，并伴有明显的脑电图变化。研究了中药制剂TJ - 960对大鼠海马CA1区神经元损伤的影响。在应用钴前一个月开始持续口服TJ - 960，结果显示其对向大脑皮层应用钴所诱导的海马神经元损伤几乎具有完全的保护作用。TJ - 960还完全抑制了脑电图变化以及钴应用所诱导的脑水肿。
