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Antimicrob Agents Chemother. 2005 Mar;49(3):873-83. doi: 10.1128/AAC.49.3.873-883.2005.
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Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients.免疫功能低下患者中的巨细胞病毒糖蛋白B混合基因型
Clin Infect Dis. 2004 Jul 15;39(2):155-61. doi: 10.1086/421496. Epub 2004 Jun 23.
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Pediatr Transplant. 2004 Jun;8 Suppl 5:19-27. doi: 10.1111/j.1398-2265.2004.00183.x.
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Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR.实时荧光定量PCR法优化血浆中巨细胞病毒DNA的定量检测
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Antiviral resistance in cytomegalovirus: an emerging problem in organ transplant recipients.巨细胞病毒中的抗病毒耐药性：器官移植受者中一个新出现的问题。
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Comparison of cytomegalovirus (CMV) UL97 gene sequences in the blood and vitreous of patients with acquired immunodeficiency syndrome and CMV retinitis.获得性免疫缺陷综合征合并巨细胞病毒视网膜炎患者血液和玻璃体中巨细胞病毒（CMV）UL97基因序列的比较。
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9
Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.用于基因型抗病毒耐药性检测的巨细胞病毒UL97基因测序。
Antimicrob Agents Chemother. 2001 Oct;45(10):2775-80. doi: 10.1128/AAC.45.10.2775-2780.2001.
10
Molecular detection of human cytomegalovirus and determination of genotypic ganciclovir resistance in clinical specimens.
Clin Infect Dis. 1995 Oct;21 Suppl 2:S170-3. doi: 10.1093/clinids/21.supplement_2.s170.

直接从患者血清样本中快速检测出赋予更昔洛韦抗性的人巨细胞病毒UL97突变。

Rapid detection directly from patient serum samples of human cytomegalovirus UL97 mutations conferring ganciclovir resistance.

作者信息

Castor Jared, Cook Linda, Corey Lawrence, Jerome Keith R

机构信息

Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA.

出版信息

J Clin Microbiol. 2007 Aug;45(8):2681-3. doi: 10.1128/JCM.00526-07. Epub 2007 May 30.

DOI:10.1128/JCM.00526-07
PMID:17537934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1951258/
Abstract

Ganciclovir-resistant cytomegalovirus can cause disease and death in transplant recipients. We describe here a rapid PCR- and sequencing-based assay for ganciclovir resistance that can be performed in 1 to 2 working days directly from patient specimens, without the need for amplification of the virus by cell culture. An evaluation of 120 sequential samples submitted for clinical testing revealed a variety of silent and amino acid mutations.

摘要

耐更昔洛韦的巨细胞病毒可导致移植受者发病和死亡。我们在此描述一种基于PCR和测序的快速检测耐更昔洛韦的方法，该方法可直接从患者标本在1至2个工作日内完成，无需通过细胞培养扩增病毒。对提交进行临床检测的120份连续样本的评估揭示了多种沉默突变和氨基酸突变。