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2
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本文引用的文献

1
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development.形态发生素到有丝分裂原：刺猬信号通路在脊椎动物神经发育中的多重作用
Nat Rev Neurosci. 2006 Oct;7(10):772-83. doi: 10.1038/nrn1990.
2
Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.音猬因子在中脑/后脑区域以空间和时间精度调节Gli激活因子和抑制因子的功能。
Development. 2006 May;133(9):1799-809. doi: 10.1242/dev.02339. Epub 2006 Mar 29.
3
New neurons follow the flow of cerebrospinal fluid in the adult brain.在成人大脑中，新的神经元沿着脑脊液流动的方向迁移。
Science. 2006 Feb 3;311(5761):629-32. doi: 10.1126/science.1119133. Epub 2006 Jan 12.
4
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.Gli2和Gli3定位于纤毛，并且需要鞭毛内运输蛋白polaris来进行加工和发挥功能。
PLoS Genet. 2005 Oct;1(4):e53. doi: 10.1371/journal.pgen.0010053. Epub 2005 Oct 28.
5
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.IFT逆向运动的丧失会破坏Smo在纤毛上的定位，并阻止Gli激活和抑制功能的表达。
Dev Biol. 2005 Nov 15;287(2):378-89. doi: 10.1016/j.ydbio.2005.08.050. Epub 2005 Oct 17.
6
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog.对响应音猬因子的静止成年神经干细胞的体内分析。
Nature. 2005 Oct 6;437(7060):894-7. doi: 10.1038/nature03994.
7
Vertebrate Smoothened functions at the primary cilium.脊椎动物的平滑蛋白在初级纤毛处发挥作用。
Nature. 2005 Oct 13;437(7061):1018-21. doi: 10.1038/nature04117. Epub 2005 Aug 31.
8
Cilia and Hedgehog responsiveness in the mouse.小鼠中的纤毛与刺猬信号通路反应性
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11325-30. doi: 10.1073/pnas.0505328102. Epub 2005 Aug 1.
9
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors.小鼠鞭毛内运输蛋白调节Gli转录因子的激活和抑制功能。
Development. 2005 Jul;132(13):3103-11. doi: 10.1242/dev.01894. Epub 2005 Jun 1.
10
Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis.成年室管膜细胞是有丝分裂后细胞，在胚胎发生过程中由放射状胶质细胞衍生而来。
J Neurosci. 2005 Jan 5;25(1):10-8. doi: 10.1523/JNEUROSCI.1108-04.2005.

脑室下区的刺猬信号通路对于干细胞的维持和新生神经元的迁移都是必需的。

Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons.

作者信息

Balordi Francesca, Fishell Gord

机构信息

Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA.

出版信息

J Neurosci. 2007 May 30;27(22):5936-47. doi: 10.1523/JNEUROSCI.1040-07.2007.

DOI:10.1523/JNEUROSCI.1040-07.2007
PMID:17537964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6672245/
Abstract

We examined the postnatal consequences of removing Hedgehog signaling within the adult stem cell niche. Although at birth the subventricular zone appears normal in mice lacking Hedgehog signaling, by postnatal day 8 it is greatly impaired, and cell death is increased. In addition, both the quiescent B stem cell population and transit-amplifying C cells become depleted postnatally. In contrast, the A cell population expands precociously, mostly fails to migrate to the olfactory bulbs, and is ultimately also depleted by postnatal day 30. In vitro and in vivo analyses demonstrate that this failure in migration is a result of nonautonomous signaling, possibly caused by a reduction in Slit1 ligand in A cells. These results suggest that Hedgehog signaling is required for the maintenance of the B and C cell populations and indirectly for the migration of the neurons that are generated from the adult stem cell niche.

摘要

我们研究了在成体干细胞生态位中去除刺猬信号通路后对出生后产生的影响。尽管在出生时，缺乏刺猬信号通路的小鼠的脑室下区看起来正常，但到出生后第8天，该区域受到严重损害，细胞死亡增加。此外，静止的B干细胞群和过渡扩增的C细胞在出生后都会减少。相比之下，A细胞群过早扩张，大部分未能迁移到嗅球，最终在出生后第30天也会减少。体外和体内分析表明，这种迁移失败是由非自主信号传导导致的，可能是由于A细胞中Slit1配体减少所致。这些结果表明，刺猬信号通路对于维持B和C细胞群是必需的，并且间接影响从成体干细胞生态位产生的神经元的迁移。