O'Dwyer Peter J, Eckhardt S Gail, Haller Daniel G, Tepper Joel, Ahnen Dennis, Hamilton Stanley, Benson Al B, Rothenberg Mace, Petrelli Nicholas, Lenz Heinz-Joseph, Diasio Robert, DuBois Raymond, Sargent Daniel, Sloan Jeff, Johnson C Daniel, Comis Robert L, O'Connell Michael J
Coalition of Cancer Cooperative Groups, Philadelphia, PA, USA.
J Clin Oncol. 2007 Jun 1;25(16):2313-21. doi: 10.1200/JCO.2006.08.6900.
Emerging technologies have greatly expanded our ability to detect, characterize, and treat colorectal cancer. The Coalition of Cancer Cooperative Groups convened a multidisciplinary panel, the Scientific Leadership Council in GI cancer, to discuss and advise on the priorities and opportunities to advance current and future approaches into the clinical arena to impact most rapidly the morbidity and mortality from this disease. The Council's recommendations for research priorities are the result of engagement of community and academic oncologists, patient advocacy groups, and other stakeholders including the pharmaceutical industry and governmental agencies. We detail some key prospects for investigation in the areas of colon cancer detection, prevention, and surgical and medical management. Many are in early or definitive clinical trials, and a focus on rapid accrual is urged. The implementation of biology-directed laboratory investigations, both in association with ongoing clinical trials and as a separate developmental strategy for targeted therapies, is supported as the route to individualized therapy.
新兴技术极大地扩展了我们检测、表征和治疗结直肠癌的能力。癌症合作组织联盟召集了一个多学科小组，即胃肠道癌症科学领导委员会，以讨论并就将当前和未来方法推进到临床领域从而最迅速地影响该疾病发病率和死亡率的优先事项和机会提供建议。该委员会关于研究优先事项的建议是社区和学术肿瘤学家、患者倡导组织以及包括制药行业和政府机构在内的其他利益相关者共同参与的结果。我们详细介绍了结肠癌检测、预防以及手术和药物治疗领域一些关键的研究前景。许多研究正处于早期或确定性临床试验阶段，并且敦促加快入组速度。支持开展以生物学为导向实验室研究，这既可以与正在进行的临床试验相结合，也可以作为靶向治疗的单独发展策略，以此作为实现个体化治疗的途径。
