MMWR Morb Mortal Wkly Rep. 2007 Jun 1;56(21):532-4.
In May 2006, the Illinois Department of Public Health (IDPH) informed CDC about a possible increase in Acanthamoeba keratitis (AK) at an ophthalmology center in Illinois during the preceding 3 years. The University of Illinois at Chicago (UIC) was investigating this possible increase. In October 2006, IDPH updated CDC about the ongoing UIC investigation. At that time, CDC informally contacted multiple ophthalmology centers in the United States to assess whether the potential increase in cases extended beyond Illinois. Responses from the ophthalmology centers were inconclusive. In January 2007, CDC initiated a retrospective survey of 22 ophthalmology centers nationwide to assess whether cases were increasing throughout the United States. In March 2007, data received from 13 centers demonstrated an increase in culture-confirmed cases of AK with wide geographic distribution. The increase in cases had begun in 2004 and continued to the present. On March 16, 2007, CDC initiated a multistate investigation to look for risk factors associated with this increase in AK cases. This report summarizes recent preliminary results of that investigation, which, indicated an association with AK in soft contact lens wearers who used Advanced Medical Optics (Santa Ana, California) Complete MoisturePlus (AMOCMP) multipurpose cleaning solution. CDC and the Food and Drug Administration (FDA) are taking steps to notify the public and the medical and public health communities of this preliminary association. The manufacturer has undertaken a voluntary recall of the product.
2006年5月，伊利诺伊州公共卫生部（IDPH）向疾病控制与预防中心（CDC）通报，在过去3年里，伊利诺伊州一家眼科中心的棘阿米巴角膜炎（AK）病例可能有所增加。伊利诺伊大学芝加哥分校（UIC）正在调查这一可能的增加情况。2006年10月，IDPH向CDC通报了UIC正在进行的调查情况。当时，CDC非正式地联系了美国多个眼科中心，以评估病例的潜在增加是否超出了伊利诺伊州范围。眼科中心的回复尚无定论。2007年1月，CDC对全国22家眼科中心开展了一项回顾性调查，以评估美国各地的病例是否在增加。2007年3月，从13家中心收到的数据显示，经培养确诊的AK病例有所增加，且分布地域广泛。病例增加始于2004年，并持续至今。2007年3月16日，CDC启动了一项多州调查，以寻找与AK病例增加相关的风险因素。本报告总结了该调查的近期初步结果，结果表明，这与使用高级医疗光学公司（加利福尼亚州圣安娜）的Complete MoisturePlus（AMOCMP）多功能清洁溶液的软性隐形眼镜佩戴者发生AK有关。CDC和食品药品监督管理局（FDA）正在采取措施，将这一初步关联告知公众以及医疗和公共卫生界。制造商已主动召回该产品。
