鸡Z染色体上癌症基因及其人类同源基因的频率：对性染色体进化的影响。
Frequency of cancer genes on the chicken z chromosome and its human homologues: implications for sex chromosome evolution.
作者信息
Stiglec Rami, Kohn Matthias, Fong James, Ezaz Tariq, Hameister Horst, Marshall Graves Jennifer A
机构信息
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra ACT 0200, Australia.
出版信息
Comp Funct Genomics. 2007;2007:43070. doi: 10.1155/2007/43070. Epub 2007 Jan 8.
It has been suggested that there are special evolutionary forces that act on sex chromosomes. Hemizygosity of the X chromosome in male mammals has led to selection for male-advantage genes, and against genes posing extreme risks of tumor development. A similar bias against cancer genes should also apply to the Z chromosome that is present as a single copy in female birds. Using comparative database analysis, we found that there was no significant underrepresentation of cancer genes on the chicken Z, nor on the Z-orthologous regions of human chromosomes 5 and 9. This result does not support the hypothesis that genes involved in cancer are selected against on the sex chromosomes.
有人提出，存在作用于性染色体的特殊进化力量。雄性哺乳动物中X染色体的半合子状态导致对雄性优势基因的选择，并淘汰那些具有极端肿瘤发展风险的基因。对癌症基因的类似偏向性也应适用于雌性鸟类中以单拷贝形式存在的Z染色体。通过比较数据库分析，我们发现鸡的Z染色体上以及人类5号和9号染色体的Z同源区域上，癌症基因并没有明显的低表达。这一结果不支持癌症相关基因在性染色体上被淘汰的假说。
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