Environ Health Perspect. 1978 Jun;24:73-80. doi: 10.1289/ehp.782473.
The currently available methods of assessing testicular toxicity and fertility are discussed. Compounds inducing testicular atrophy mainly affect the seminiferous epithelium, with progressive loss of spermatozoa, spermatids, spermatocytes, and spermatogonia. Quantitative histometric analysis of spermatogenesis, together with hormone assays, could be used to advantage in defining the underlying mechanisms of toxicity.
目前用于评估睾丸毒性和生育力的方法进行了讨论。导致睾丸萎缩的化合物主要影响生精上皮，导致精子、精母细胞、精原细胞和精原细胞逐渐丢失。对精子发生进行定量组织学分析，结合激素检测，可有助于确定毒性的潜在机制。
